{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:07:57Z","timestamp":1791338877597,"version":"4.3.1"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T00:00:00Z","timestamp":1395187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2014,6,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Cyclin D1 expression has been reported in a subset of patients with diffuse large B\u2010cell leukemia (DLBCL), but studies have been few and generally small, and they have demonstrated no obvious clinical implications attributable to cyclin D1 expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors reviewed 1435 patients who were diagnosed with DLBCL as part of the International DLBCL rituximab with cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone (R\u2010CHOP) Consortium Program and performed clinical, immunohistochemical, and genetic analyses with a focus on cyclin D1. All patients who were cyclin D1\u2010positive according to immunohistochemistry were also assessed for rearrangements of the cyclin D1 gene (<jats:italic>CCND1<\/jats:italic>) using fluorescence in situ hybridization. Gene expression profiling was performed to compare patients who had DLBCL with and without cyclin D1 expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In total, 30 patients (2.1%) who had DLBCL that expressed cyclin D1 and lacked <jats:italic>CCND1<\/jats:italic> gene rearrangements were identified. Patients with cyclin D1\u2010positive DLBCL had a median age of 57 years (range, 16.0\u201082.6 years). There were 23 males and 7 females. Twelve patients (40%) had bulky disease. None of them expressed CD5. Two patients expressed cyclin D2. Gene expression profiling indicated that 17 tumors were of the germinal center type, and 13 were of the activated B\u2010cell type. Genetic aberrations of B\u2010cell leukemia\/lymphoma 2 (<jats:italic>BCL2<\/jats:italic>), <jats:italic>BCL6<\/jats:italic>, v\u2010myc avian myelocytomatosis viral oncogene homolog (<jats:italic>MYC<\/jats:italic>), mouse double minute 2 oncogene E3 ubiquitin protein ligase (<jats:italic>MDM2<\/jats:italic>), <jats:italic>MDM4<\/jats:italic>, and tumor protein 53 (<jats:italic>TP53<\/jats:italic>) were rare or absent. Gene expression profiling did not reveal any striking differences with respect to cyclin D1 in DLBCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Compared with patients who had cyclin D1\u2010negative DLBCL, men were more commonly affected with cyclin D1\u2010positive DLBCL, and they were significantly younger. There were no other significant differences in clinical presentation, pathologic features, overall survival, or progression\u2010free survival between these two subgroups of patients with DLBCL. <jats:bold><jats:italic>Cancer<\/jats:italic> 2014;120:1818\u20131829<\/jats:bold>. \u00a9 <jats:italic>2014 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28664","type":"journal-article","created":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T22:41:23Z","timestamp":1395268883000},"page":"1818-1829","source":"Crossref","is-referenced-by-count":38,"title":["Prevalence and clinical implications of cyclin D1 expression in diffuse large B\u2010cell lymphoma (DLBCL) treated with immunochemotherapy: A report from the International DLBCL Rituximab\u2010CHOP Consortium Program"],"prefix":"10.1002","volume":"120","author":[{"given":"Chi Young","family":"Ok","sequence":"first","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijun Y.","family":"Xu\u2010Monette","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandar","family":"Tzankov","sequence":"additional","affiliation":[{"name":"Department of Pathology Basel University Hospital  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis P.","family":"O'Malley","sequence":"additional","affiliation":[{"name":"Clarient Pathology Laboratory Aliso Viejo California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Montes\u2010Moreno","sequence":"additional","affiliation":[{"name":"Marques de Valdecilla University Hospital  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Visco","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, San Bortolo Hospital  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Pathology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Dybk\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine\/Hematology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attilio","family":"Orazi","sequence":"additional","affiliation":[{"name":"Department of Pathology Weill Medical College of Cornell University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youli","family":"Zu","sequence":"additional","affiliation":[{"name":"Department of Pathology The Methodist Hospital Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govind","family":"Bhagat","sequence":"additional","affiliation":[{"name":"Department of Pathology College of Physicians and Surgeons, Columbia University Medical Center and New York Presbyterian Hospital New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy L.","family":"Richards","sequence":"additional","affiliation":[{"name":"Department of Medicine University of North Carolina School of Medicine Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Hsi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology The Cleveland Clinic  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Han van Krieken","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Nijmegen Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurilio","family":"Ponzoni","sequence":"additional","affiliation":[{"name":"Department of Pathology San Raffaele H. 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