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The surgical approach has undergone significant changes thanks to a better understanding of the natural history of the different histologic subtypes, the importance of site, and the different sensitivity to available drugs. The soft tissue tumor family includes 3 major, distinct categories: desmoid\u2010type fibromatosis, soft tissue sarcoma, and gastrointestinal stromal tumor. In general, limb\u2010sparing and function\u2010sparing approaches should be used when feasible for tumors located in the extremities and girdles. Resections of adherent structures\/viscera, which may be close but not invaded, may be needed in tumors arising in the retroperitoneum\/abdomen to minimize microscopic intralesional margins, maximize local tumor control, and possibly improve survival. Margins of resection and the use of adjuvant\/neadjuvant radiation therapy and\/or chemotherapy are contingent on an accurate histologic diagnosis. Treatment planning should include multidisciplinary consultation to determine optimal therapy, taking into consideration tumor histology, site and extent of the disease, its natural history and sensitivity to available treatments, surgical challenges, and\u2014of course\u2014quality of life. <jats:bold><jats:italic>Cancer<\/jats:italic> 2014;120:2638\u20132648.<\/jats:bold> \u00a9 <jats:italic>2014 American Cancer Society<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/cncr.28715","type":"journal-article","created":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T22:00:09Z","timestamp":1397772009000},"page":"2638-2648","source":"Crossref","is-referenced-by-count":50,"title":["Surgical management of localized soft tissue tumors"],"prefix":"10.1002","volume":"120","author":[{"given":"Alessandro","family":"Gronchi","sequence":"first","affiliation":[{"name":"Department of Surgery, Sarcoma Service Scientific Institute for Research and Treatment (IRCCS) Foundation, National Cancer Institute 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