{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T20:09:59Z","timestamp":1772482199943,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T00:00:00Z","timestamp":1402358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2014,9,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The Prostate Cancer Prevention Trial risk calculator for high\u2010grade (PCPTHG) prostate cancer (CaP) was developed to improve the detection of clinically significant CaP. In this study, the authors compared the performance of the PCPTHG against multiparametric magnetic resonance imaging (MP\u2010MRI) in predicting men at risk of CaP.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Men with an abnormal prostate\u2010specific antigen (PSA) level or digital rectal examination (DRE) and a suspicious lesion on a 3\u2010Tesla MP\u2010MRI were enrolled prospectively. Three radiologists reviewed and graded all lesions on a 5\u2010point Likert scale. Biopsy of suspicious lesion(s) was performed using a proprietary MRI\/transrectal ultrasound fusion\u2010guided prostate biopsy system, after which 12\u2010core biopsy was performed. A genitourinary pathologist reviewed all pathology slides. The performance of PCPTHG was compared with that of MP\u2010MRI in predicting clinically significant CaP.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of 175 men who were eligible for analysis, 64.6% (113 of 175 men) were diagnosed with CaP, including 93 of 113 men (82.3%) who had clinically significant disease. Age, abnormal DRE, PSA, PSA density, prostate size, extraprostatic extension on MRI, apparent diffusion coefficient value, and MRI lesion size were identified as significant predictors of high\u2010grade CaP (all <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). The area under the receiver operating characteristic curve of PCPTHG for predicting high\u2010grade CaP was 0.676 (95% confidence interval [CI], 0.592\u20100.751). By using a risk cutoff of \u226515% for biopsy as, proposed previously for high\u2010grade CaP, sensitivity was 96.4%, specificity was 7.6%, and the false\u2010positive rate was 51.1%. In contrast, the area under the receiver operating characteristic curve of MP\u2010MRI for high\u2010grade CaP was 0.769 (95% CI, 0.703\u20100.834), and it was 0.812 (95% CI, 0.754\u20100.869) for clinically significant CaP.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>MP\u2010MRI outperforms PCPTHG in predicting clinically significant CaP, and its application may help select patients who will benefit from CaP diagnosis and treatment. <jats:bold><jats:italic>Cancer<\/jats:italic> 2014;120:2876\u20132882.<\/jats:bold> \u00a9  <jats:italic>2014 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28790","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T19:52:56Z","timestamp":1402429976000},"page":"2876-2882","source":"Crossref","is-referenced-by-count":50,"title":["Multiparametric magnetic resonance imaging outperforms the Prostate Cancer Prevention Trial risk calculator in predicting clinically significant prostate cancer"],"prefix":"10.1002","volume":"120","author":[{"given":"Simpa S.","family":"Salami","sequence":"first","affiliation":[{"name":"The Arthur Smith Institute for Urology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park New York"},{"name":"Department of Pathology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish A.","family":"Vira","sequence":"additional","affiliation":[{"name":"The Arthur Smith Institute for Urology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park New York"},{"name":"Department of Pathology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baris","family":"Turkbey","sequence":"additional","affiliation":[{"name":"Department of Pathology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park New York"},{"name":"Molecular Imaging Program National Institutes of Health Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew","family":"Fakhoury","sequence":"additional","affiliation":[{"name":"The Arthur Smith Institute for Urology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park New York"},{"name":"Department of Pathology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana","family":"Yaskiv","sequence":"additional","affiliation":[{"name":"Department of Pathology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park New York"},{"name":"Molecular Imaging Program National Institutes of Health Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Villani","sequence":"additional","affiliation":[{"name":"Department of Pathology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park New York"},{"name":"Department of Diagnostic and Interventional Radiology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eran","family":"Ben\u2010Levi","sequence":"additional","affiliation":[{"name":"Department of Pathology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park New York"},{"name":"Department of Diagnostic and Interventional Radiology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ardeshir R.","family":"Rastinehad","sequence":"additional","affiliation":[{"name":"The Arthur Smith Institute for Urology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park New York"},{"name":"Department of Pathology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park New York"},{"name":"Department of Diagnostic and Interventional Radiology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park New 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