{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:12:51Z","timestamp":1790932371947,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T00:00:00Z","timestamp":1402531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2014,10,15]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Uterine leiomyosarcoma (ULMS) is identified in 0.1% to 0.2% of hysterectomy specimens of presumed leiomyoma. To date, there is no preoperative technique that reliably differentiates ULMS from uterine leiomyoma. Increasing use of minimally invasive approaches for the management of leiomyomas may result in inadvertently morcellated ULMS with resultant intraperitoneal dissemination of tumor. The objective of this study was to assess the impact of intraperitoneal morcellation on the outcomes of patients with ULMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In this retrospective cohort study, all patients with ULMS who attended the authors' institutions from 2007 to 2012 were reviewed. Demographics and outcomes were compared between those who underwent morcellation or total abdominal hysterectomy (TAH) as their first surgery for uterus\u2010limited ULMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In total, 58 patients were identified, including 39 who underwent TAH and 19 who underwent intraperitoneal morcellation. Intraperitoneal morcellation was associated with a significantly increased risk of abdominal\/pelvic recurrences (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.001) and with significantly shorter median recurrence\u2010free survival (10.8 months vs 39.6 months;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.002). A multivariate adjusted model demonstrated a &gt;3 times increased risk of recurrence associated with morcellation (hazard ratio, 3.18; 95% confidence interval, 1.5\u20106.8;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Intraperitoneal morcellation of presumed leiomyoma worsens the outcomes of women with ULMS. Because there are no reliable preoperative techniques to distinguish ULMS from benign leiomyoma, all efforts to minimize intraperitoneal uterine morcellation should be considered. [See editorial on pages 000\u2010000, this issue.]\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2014;120:3154\u20133158.\n                      <\/jats:bold>\n                      \u00a9\n                      <jats:italic>2014 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.28844","type":"journal-article","created":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T11:13:25Z","timestamp":1402571605000},"page":"3154-3158","source":"Crossref","is-referenced-by-count":173,"title":["Retrospective cohort study evaluating the impact of intraperitoneal morcellation on outcomes of localized uterine leiomyosarcoma"],"prefix":"10.1002","volume":"120","author":[{"given":"Suzanne","family":"George","sequence":"first","affiliation":[{"name":"Center for Sarcoma and Bone Oncology, Dana\u2010Farber Cancer Institute, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Barysauskas","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology Dana\u2010Farber Cancer Institute Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Serrano","sequence":"additional","affiliation":[{"name":"Center for Sarcoma and Bone Oncology, Dana\u2010Farber Cancer Institute, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titilope","family":"Oduyebo","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Rauh\u2010Hain","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela G.","family":"Del Carmen","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D.","family":"Demetri","sequence":"additional","affiliation":[{"name":"Center for Sarcoma and Bone Oncology, Dana\u2010Farber Cancer Institute, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Muto","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/94.4.435"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03622-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2006.01.010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2008.02.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)91298-Q"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050058"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000010172"},{"key":"e_1_2_7_9_1","first-page":"399","article-title":"The epidemiology of sarcomas of the uterus","volume":"76","author":"Harlow BL","year":"1986","journal-title":"J Natl Cancer 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NCCN Clinical Practice Guidelines in Soft Tissue Sarcoma. Version 1.2013. Fort Washington PA: NCCN; 2013 Available at:http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/sarcoma.pdf. Accessed December 2013."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.4074"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.181.5.1811369"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2009.03.005"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.28844","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.28844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T21:46:09Z","timestamp":1760305569000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.28844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,12]]},"references-count":24,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2014,10,15]]}},"alternative-id":["10.1002\/cncr.28844"],"URL":"https:\/\/doi.org\/10.1002\/cncr.28844","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718448508.793506257","asserted-by":"object"}]},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,12]]}}}