{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:48:41Z","timestamp":1787647721448,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T00:00:00Z","timestamp":1407110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KM1CA156687"],"award-info":[{"award-number":["KM1CA156687"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The objective of this study was to elucidate relative preferences of women with ovarian cancer for symptoms, treatment\u2010related side effects, and progression\u2010free survival (PFS) relevant to choosing a treatment regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Women with advanced or recurrent ovarian cancer participated in a survey that included 3 methods to measure patient preferences (ratings, rankings, and a discrete\u2010choice experiment) for 7 attributes: mode of administration, visit frequency, peripheral neuropathy, nausea and vomiting, fatigue, abdominal discomfort, and PFS. Participants were asked to choose between 2 unlabeled treatment scenarios that were characterized using the 7 attributes. Each participant completed 12 choice questions in which attribute levels were assigned according to an experimental design and a fixed\u2010choice question representing 2 chemotherapy regimens for ovarian cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In total, 95 women completed the survey. Participants' ratings and rankings revealed greater concern and importance for PFS than for any other attribute (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001 for all). The discrete\u2010choice experiment revealed that the relative odds that a participant would choose a scenario with 18 months, 21 months, and 24 months of PFS versus 15 months of PFS were 1.5 (<jats:italic>P<\/jats:italic>\u2009=\u2009.01), 3.4 (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), and 7.5 (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), respectively. However, participants' choices indicated that they were willing to accept a shorter PFS to avoid severe side effects: 6.7 months to reduce nausea and vomiting from severe to mild, 5.0 months to reduce neuropathy from severe to mild, and 3.7 months to reduce abdominal symptoms from severe to moderate.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>PFS is the predominant driver of patient preferences for chemotherapy regimens. However, women in the current study were willing to trade significant PFS time for reductions in treatment\u2010related toxicity. <jats:bold><jats:italic>Cancer<\/jats:italic> 2014;120:3651\u20133659<\/jats:bold>. \u00a9 <jats:italic>2014 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28940","type":"journal-article","created":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T16:48:36Z","timestamp":1407170916000},"page":"3651-3659","source":"Crossref","is-referenced-by-count":72,"title":["Patient preferences in advanced or recurrent ovarian cancer"],"prefix":"10.1002","volume":"120","author":[{"given":"Laura J.","family":"Havrilesky","sequence":"first","affiliation":[{"name":"Division of Gynecologic Oncology Department of Obstetrics and Gynecology Duke University Medical Center Durham North Carolina"},{"name":"Duke Cancer Institute, Duke University Medical Center Durham North 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Durham North Carolina"},{"name":"Duke Translational Medicine Institute Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy P.","family":"Abernethy","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute, Duke University Medical Center Durham North Carolina"},{"name":"Division of Medical Oncology Duke University Medical Center Durham North Carolina"},{"name":"Department of Medicine Duke University Medical Center Durham North Carolina"},{"name":"Duke Translational Medicine Institute Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby D.","family":"Reed","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute, Duke University Medical Center Durham North Carolina"},{"name":"Department of Medicine Duke University Medical Center Durham North Carolina"},{"name":"Duke Translational Medicine Institute Durham North 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