{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:36Z","timestamp":1786977516415,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T00:00:00Z","timestamp":1406764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["058799"],"award-info":[{"award-number":["058799"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["MRSG-08-110-01-CCE"],"award-info":[{"award-number":["MRSG-08-110-01-CCE"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Endocrine measures of ovarian reserve\n                      <jats:italic>before<\/jats:italic>\n                      breast cancer treatment may predict postchemotherapy ovarian function, providing prognostic information at the time of cancer diagnosis. The objectives of this study were 1) to determine whether prechemotherapy levels of antimullerian hormone (AMH), follicle\u2010stimulating hormone (FSH), and inhibin B (inhB) are associated with the return of ovarian function after chemotherapy and 2) to generate a prognostic score for ovarian recovery in young women with breast cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A prospective cohort study recruited 109 participants (median age, 39 years; age range, 23\u201045 years) before chemotherapy from 2 breast clinics and followed them longitudinally. By using time\u2010to\u2010event analysis, the authors tested the association between prechemotherapy AMH, FSH, and inhB levels and the time to return of ovarian function, as measured by menstrual pattern.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      After a median follow\u2010up of 163 days (range, 4\u20101009 days) after chemotherapy, 62 participants (57%) experienced return of ovarian function. In adjusted analyses, AMH levels &gt;0.7 ng\/mL (hazard ratio, 2.9; 95% confidence interval, 1.5\u20105.6) and FSH levels \u226410 IU\/L (hazard ratio, 4.7; 95% confidence interval, 1.3\u201016.8) were associated with a shorter time to ovarian recovery, whereas inhB levels were not related. A prognostic score based on age &lt;40 years, AMH &gt;0.7 ng\/mL, and body mass index \u226525 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      was used to estimate the timing of recovery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      In reproductive\u2010aged women with newly diagnosed breast cancer, prechemotherapy AMH and FSH levels were associated with the return of ovarian function, independent of age. A novel prognostic score incorporating AMH, age, and body size was capable of estimating the time to ovarian recovery. Pending validation, these data support using prechemotherapy ovarian reserve measures, particularly AMH, to prospectively counsel young patients on future ovarian function. Because ovarian function is not equivalent to fertility, follow\u2010up studies on predicting fertility are needed.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2014;120:3691\u20133698\n                      <\/jats:bold>\n                      . \u00a9\n                      <jats:italic>2014 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.28942","type":"journal-article","created":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T10:33:54Z","timestamp":1406802834000},"page":"3691-3698","source":"Crossref","is-referenced-by-count":64,"title":["Prechemotherapy antimullerian hormone, age, and body size predict timing of return of ovarian function in young breast cancer patients"],"prefix":"10.1002","volume":"120","author":[{"given":"Hui\u2010Chun 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