{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:23:03Z","timestamp":1766157783629,"version":"build-2065373602"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T00:00:00Z","timestamp":1411430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R25CA116339"],"award-info":[{"award-number":["R25CA116339"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of North Carolina Universiy Cancer Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The objective of the current study was to evaluate the effect of obesity on pretreatment quality of life (QoL) in gynecologic oncology patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors analyzed collected data from an institution\u2010wide cohort study of women with gynecologic cancers enrolled from August 2012 to June 2013. The Functional Assessment of Cancer Therapy\u2010General, site\u2010specific symptom scales, and the National Institutes of Health Patient\u2010Reported Outcomes Measurement Information System (PROMIS) global mental and physical health tools were administered. Survey results were linked to clinical data abstracted from medical records (demographics and comorbid conditions). Bivariate tests and multivariate linear regression models were used to evaluate factors associated with QoL scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 182 women with ovarian, uterine, cervical, and vulvar\/vaginal cancers were identified; of these, 152 (84%) were assessed before surgery. Mean body mass index was 33.5 kg\/m<jats:sup>2<\/jats:sup> and race included white (120 patients [79%]), black (22 patients [15%]), and other (10 patients [6.5%]). A total of 98 patients (64.5%) were obese (body mass index \u226530). On multivariate analysis, subscales for functional (17 vs 19; <jats:italic>P<\/jats:italic>\u2009=\u2009.04), emotional (16 vs 19; <jats:italic>P<\/jats:italic>\u2009=\u2009.008), and social (22 vs 24; <jats:italic>P<\/jats:italic>\u2009=\u2009.02) well\u2010being as well as overall Functional Assessment of Cancer Therapy\u2010General scores (77 vs 86; <jats:italic>P<\/jats:italic>\u2009=\u2009.002) and Patient\u2010Reported Outcomes Measurement Information System global physical health scores (45 vs 49; <jats:italic>P<\/jats:italic>\u2009=\u2009.003) were found to be significantly lower in obese versus nonobese patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Before cancer treatment, obese patients with gynecologic malignancies appear to have worse baseline QoL than their normal\u2010weight counterparts. Emerging models of QoL\u2010based cancer outcome measures may disproportionately affect populations with a high obesity burden. The potential disparate impact of cancer therapy on longitudinal QoL in the obese versus nonobese patients needs to be evaluated. <jats:bold><jats:italic>Cancer<\/jats:italic> 2015;121:395\u2013402.<\/jats:bold> \u00a9 <jats:italic>2014 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.29061","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T10:47:28Z","timestamp":1411469248000},"page":"395-402","source":"Crossref","is-referenced-by-count":25,"title":["Obesity is associated with worse quality of life in women with gynecologic malignancies: An opportunity to improve patient\u2010centered outcomes"],"prefix":"10.1002","volume":"121","author":[{"given":"Kemi M.","family":"Doll","sequence":"first","affiliation":[{"name":"Division of Gynecologic Oncology University of North Carolina School of Medicine Chapel Hill North Carolina"},{"name":"Cancer Care Quality Training Program, Division of Health Policy and Management Gillings School of Global Public Health, University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison K.","family":"Kalinowski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of North Carolina School of Medicine Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna C.","family":"Snavely","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra E.","family":"Irwin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Gillings School of Global Public Health, University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannette T","family":"Bensen","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria L.","family":"Bae\u2010Jump","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology University of North Carolina School of Medicine Chapel Hill North Carolina"},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology University of North Carolina School of Medicine Chapel Hill North Carolina"},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Van Le","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology University of North Carolina School of Medicine Chapel Hill North Carolina"},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel L.","family":"Clarke\u2010Pearson","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology University of North Carolina School of Medicine Chapel Hill North Carolina"},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola A.","family":"Gehrig","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology University of North Carolina School of Medicine Chapel Hill North 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