{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:30:25Z","timestamp":1792668625397,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T00:00:00Z","timestamp":1411430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The treatment and outcomes of patients with human immunodeficiency virus (HIV)\u2010associated Hodgkin lymphoma (HL) continue to evolve. The International Prognostic Score (IPS) is used to predict the survival of patients with advanced\u2010stage HL, but it has not been validated in patients with HIV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This was a multi\u2010institutional, retrospective study of 229 patients with HIV\u2010associated, advanced\u2010stage, classical HL who received doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) plus combination antiretroviral therapy. Their clinical characteristics were presented descriptively, and multivariate analyses were performed to identify the factors that were predictive of response and prognostic of progression\u2010free survival (PFS) and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The overall and complete response rates to ABVD in patients with HIV\u2010associated HL were 91% and 83%, respectively. After a median follow\u2010up of 5 years, the 5\u2010year PFS and OS rates were 69% and 78%, respectively. In multivariate analyses, there was a trend toward an IPS score &gt;3 as an adverse factor for PFS (hazard ratio [HR], 1.49; <jats:italic>P<\/jats:italic>=.15) and OS (HR, 1.84; <jats:italic>P<\/jats:italic>=.06). A cluster of differentiation 4 (CD4)\u2010positive (T\u2010helper) cell count &lt;200 cells\/\u03bcL was associated independently with both PFS (HR, 2.60; <jats:italic>P<\/jats:italic>=.002) and OS (HR, 2.04; <jats:italic>P<\/jats:italic>=.04). The CD4\u2010positive cell count was associated with an increased incidence of death from other causes (HR, 2.64; <jats:italic>P<\/jats:italic>=.04) but not with death from HL\u2010related causes (HR, 1.55; <jats:italic>P<\/jats:italic>=.32).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The current results indicate excellent response and survival rates in patients with HIV\u2010associated, advanced\u2010stage, classical HL who receive ABVD and combination antiretroviral therapy as well as the prognostic value of the CD4\u2010positive cell count at the time of lymphoma diagnosis for PFS and OS. <jats:bold><jats:italic>Cancer<\/jats:italic> 2015;121:423\u2013431.<\/jats:bold> \u00a9 <jats:italic>2014 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.29066","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T10:29:49Z","timestamp":1411468189000},"page":"423-431","source":"Crossref","is-referenced-by-count":36,"title":["Prognostic factors for advanced\u2010stage human immunodeficiency virus\u2010associated classical Hodgkin lymphoma treated with doxorubicin, bleomycin, vinblastine, and dacarbazine plus combined antiretroviral therapy: A multi\u2010institutional retrospective study"],"prefix":"10.1002","volume":"121","author":[{"given":"Jorge J.","family":"Castillo","sequence":"first","affiliation":[{"name":"Division of Hematologic Malignancies Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Bower","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Chelsea and Westminster Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9my","family":"Br\u00fchlmann","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Infectious Diseases Bern University Hospital and the University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urban","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Infectious Diseases Bern University Hospital and the University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansjakob","family":"Furrer","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Infectious Diseases Bern University Hospital and the University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Y.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Section of Hematology Emilio Ribas Institute for Infectious Diseases Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Besson","sequence":"additional","affiliation":[{"name":"Clinical Hematology Unit Bicetre Hospital, University Paris Sud, INSERM U1012 Le Kremlin\u2010Bicetre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Montoto","sequence":"additional","affiliation":[{"name":"Center for Hemato\u2010Oncology Barts Cancer Institute London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Cwynarski","sequence":"additional","affiliation":[{"name":"Department of Hematology Royal Free Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy S.","family":"Abramson","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Dalia","sequence":"additional","affiliation":[{"name":"Division of Malignant Hematology H. Lee Moffitt Cancer Center and Research Institute Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Bibas","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Hematology Lazzaro Spallanzani National Institute for Infectious Diseases Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Connors","sequence":"additional","affiliation":[{"name":"British Columbia Cancer Agency Center for Lymphoid Cancer Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Furman","sequence":"additional","affiliation":[{"name":"Department of Medicine Rhode Island Hospital\/The Miriam Hospital Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh\u2010Ly","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy P.","family":"Cooley","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Boston Medical Center Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brady E.","family":"Beltran","sequence":"additional","affiliation":[{"name":"Department of Oncology and Radiotherapy Edgardo Rebagliati Martins National Hospital Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime A.","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Guillermo Almenara Irigoyen National Hospital Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Vose","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of Nebraska Medical Center Omaha 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