{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:31:29Z","timestamp":1789194689803,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T00:00:00Z","timestamp":1413849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2015,2,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The objective of this study was to investigate the prognostic value of the pretreatment circulating neutrophil count (CNC), circulating monocyte count (CMC), and circulating lymphocyte count (CLC) in human papillomavirus (HPV)\u2013related (HPV+) and HPV\u2010unrelated (HPV\u2013) oropharyngeal cancer (OPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>All p16\u2010confirmed HPV+ and HPV\u2013 OPC cases treated with chemoradiotherapy from 2000 to 2010 were included. Overall survival (OS) and recurrence\u2010free survival (RFS) were compared for high and low CNCs, CMCs, and CLCs (dichotomized by median values). A multivariate analysis (MVA) confirmed their prognostic value in HPV+ and HPV\u2013 tumors, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Five hundred ten HPV+ OPC cases and 192 HPV\u2013 OPC cases were included. The HPV+ cohort had lower CNC and CMC values but a CLC similar to that of the HPV\u2013 patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). The median follow\u2010up was 4.8 years. In the HPV+ cohort, a high CNC or CMC correlated with reduced OS and RFS in comparison with a low CNC or CMC (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01 for all), but no difference was evident in OS (<jats:italic>P<\/jats:italic>\u2009=\u2009.30) or RFS (<jats:italic>P<\/jats:italic>\u2009=\u2009.10) with the CLC. MVA confirmed that a higher CNC or CMC independently predicted lower OS (hazard ratio [HR] for CNC, 1.14, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01; HR for CMC, 2.95, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) and lower RFS (HR for CNC, 1.11, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01; HR for CMC, 3.39, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01), whereas a higher CLC was associated with higher RFS (HR, 0.66, <jats:italic>P<\/jats:italic>\u2009=\u2009.03) and marginally higher OS (HR, 0.80, <jats:italic>P<\/jats:italic>\u2009=\u2009.08). In the HPV\u2013 cohort, CNC, CMC, and CLC were not predictive of OS (<jats:italic>P<\/jats:italic>\u2009=\u2009.16, <jats:italic>P<\/jats:italic>\u2009=\u2009.86, and <jats:italic>P<\/jats:italic>\u2009=\u2009.14) or RFS (<jats:italic>P<\/jats:italic>\u2009=\u2009.61, <jats:italic>P<\/jats:italic>\u2009=\u2009.59, and <jats:italic>P<\/jats:italic>\u2009=\u2009.62).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This relatively large cohort study demonstrates that a high CNC and a high CMC independently predict inferior OS and RFS, whereas a high CLC predicts better RFS and marginally better OS in HPV+ OPC patients. This association was not apparent in HPV\u2013 patients. <jats:bold><jats:italic>Cancer<\/jats:italic> 2015;121:545\u2013555.<\/jats:bold> \u00a9 <jats:italic>2014 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.29100","type":"journal-article","created":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T10:58:16Z","timestamp":1413889096000},"page":"545-555","source":"Crossref","is-referenced-by-count":131,"title":["Prognostic value of pretreatment circulating neutrophils, monocytes, and lymphocytes in oropharyngeal cancer stratified by human papillomavirus status"],"prefix":"10.1002","volume":"121","author":[{"given":"Shao Hui","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre\/University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Waldron","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre\/University of Toronto Toronto Canada"},{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Princess Margaret Cancer Centre\/University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Milosevic","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre\/University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Princess Margaret Cancer Centre\/University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolie","family":"Ringash","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre\/University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Princess Margaret Cancer Centre\/University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre\/University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayardo","family":"Perez\u2010Ordonez","sequence":"additional","affiliation":[{"name":"Department of Pathology Princess Margaret Cancer Centre\/University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Weinreb","sequence":"additional","affiliation":[{"name":"Department of Pathology Princess Margaret Cancer Centre\/University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Bayley","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre\/University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre\/University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hope","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre\/University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.C. 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