{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:49:29Z","timestamp":1770972569645,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T00:00:00Z","timestamp":1418083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>This prospective study was undertaken to assess toxicity, resectability, and survival in pancreatic adenocarcinoma patients presenting with locally advanced, unresectable disease treated with neoadjuvant gemcitabine, docetaxel, and capecitabine (GTX) and gemcitabine and capecitabine (GX)\/radiation therapy (RT).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>All patients presenting to the Pancreas Center were evaluated for eligibility. Forty\u2010five patients (mean age, 64 years; range, 44\u201083 years)\u201434 patients deemed unresectable because of arterial involvement and 11 patients deemed unresectable because of extensive venous involvement\u2014were treated with 6 cycles of GTX. Those with arterial involvement were treated with GX\/RT after chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The GTX and GX\/RT treatments were tolerated with the expected drug\u2010related toxicities. There were no bowel perforations, cases of pancreatitis, or delayed strictures. Among those with arterial involvement, 29 underwent subsequent resection, with 20 (69%) achieving R0 resections. All 11 patients with venous\u2010only involvement underwent resection, with 8 achieving R0 resections and 3 achieving complete pathologic responses. For the arterial arm, the 1\u2010year survival rate was 71% (24 of 34 patients), and the median survival was 29 months (95% confidence interval, 21\u201038 months). Thirteen patients (38%) have not relapsed (range, 5\u201049+ months). For the venous arm, the median survival has not been reached at more than 42 months. Six patients (55%) in the venous arm did not experience recurrence (range, 6.2\u201042+ months).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>GTX plus GX\/RT is an effective neoadjuvant regimen that can be safely administered to patients up to at least the age of 83 years. It is associated with a high response rate, a high rate of R0 resections, and prolonged overall survival. <jats:bold><jats:italic>Cancer<\/jats:italic> 2015;121:673\u2013680.<\/jats:bold> \u00a9 <jats:italic>2014 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.29112","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T14:30:32Z","timestamp":1418135432000},"page":"673-680","source":"Crossref","is-referenced-by-count":38,"title":["Neoadjuvant gemcitabine, docetaxel, and capecitabine followed by gemcitabine and capecitabine\/radiation therapy and surgery in locally advanced, unresectable pancreatic adenocarcinoma"],"prefix":"10.1002","volume":"121","author":[{"given":"William H.","family":"Sherman","sequence":"first","affiliation":[{"name":"Pancreas Center Columbia University New York New 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