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SNPs for 4 cytokine genes (interleukin 6 [<jats:italic>IL6<\/jats:italic>] \u2212174G&gt;C, <jats:italic>IL1\u03b2<\/jats:italic> \u2212511C&gt;T, tumor necrosis factor \u03b1 [<jats:italic>TNF\u03b1<\/jats:italic>] \u2212308G&gt;A, and <jats:italic>IL10<\/jats:italic> \u22121082G&gt;A) were tested. Logistic regression models were used to identify SNPs that might predict moderate\/severe symptoms (rated \u22654 on the MDASI\u2010MM 0\u201010 scale). For the evaluation of the relationship between SNPs and overall symptom burden, a 2\u2010step cluster analysis was used to divide patients into subgroups with high or low symptom levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Forty\u2010one percent of the 344 patients enrolled had a high overall symptom burden. The most prevalent moderate\/severe symptoms were fatigue (47%), pain (42%), numbness (38%), and bone aches (32%). For non\u2010Hispanic whites, the <jats:italic>IL1\u03b2<\/jats:italic> \u2212511 CC genotype was associated with a high overall symptom burden (odds ratio [OR], 2.35; 95% confidence interval [CI], 1.25\u20104.72; <jats:italic>P<\/jats:italic>\u2009=\u2009.004), whereas the <jats:italic>IL6<\/jats:italic> \u2212174 GG genotype predicted less moderate\/severe fatigue (OR, 0.53; 95% CI, 0.29\u20100.88; <jats:italic>P<\/jats:italic>\u2009=\u2009.013). For other patients, the <jats:italic>IL6<\/jats:italic> \u2212174 GG genotype predicted moderate\/severe pain (OR, 3.36; 95% CI, 1.23\u201013.64; <jats:italic>P<\/jats:italic>\u2009=\u2009.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>These results support growing evidence showing that inflammation is associated with cancer\u2010related symptoms, and they suggest that racial\/ethnic factors contribute to this association. <jats:bold><jats:italic>Cancer 2015;121:1138\u20131146<\/jats:italic>.<\/jats:bold> \u00a9 <jats:italic>2014 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.29154","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T01:28:26Z","timestamp":1417570106000},"page":"1138-1146","source":"Crossref","is-referenced-by-count":24,"title":["Racial\/ethnic disparities in inflammatory gene single\u2010nucleotide polymorphisms as predictors of a high risk for symptom burden in patients with multiple myeloma 1 year after diagnosis"],"prefix":"10.1002","volume":"121","author":[{"given":"Qiuling","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Symptom Research The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin Shelley","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Symptom Research The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guojun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina D.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Z.","family":"Orlowski","sequence":"additional","affiliation":[{"name":"Department of Lymphoma\/Myeloma The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loretta A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Symptom Research The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tito R.","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Department of Symptom Research The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles S.","family":"Cleeland","sequence":"additional","affiliation":[{"name":"Department of Symptom Research The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"National Cancer Institute. 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