{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T08:58:49Z","timestamp":1771577929205,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01CA154292"],"award-info":[{"award-number":["P01CA154292"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN261201100031C"],"award-info":[{"award-number":["HHSN261201100031C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54 CA163303"],"award-info":[{"award-number":["U54 CA163303"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Although healthy women aged 65 years have a life expectancy of 20 years, there is a paucity of data on the performance of digital screening mammography among these women. The authors examined the performance and outcomes of digital screening mammography among a national group of women aged \u226565 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>From Breast Cancer Surveillance Consortium data for the years 2005 to 2011, the authors included 296,496 full\u2010field digital screening mammograms among 133,042 women ages \u226565 years without a history of breast cancer. Sensitivity, specificity, positive predictive value (PPV<jats:sub>1<\/jats:sub>), recall rates, and 95% confidence intervals (95% CIs) were calculated across the spectrum of age and breast density. Multivariate logistic regression was used to compare mammography accuracy, cancer\u2010detection rates (CDRs), and tumor characteristics by age and breast density.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Multivariate analyses revealed a significant decrease in the recall rate with age (<jats:italic>P<\/jats:italic> for linear trend [<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>]\u2009&lt;\u2009.001) and significant increases in specificity, PPV<jats:sub>1<\/jats:sub>, and CDR with age (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009&lt;\u2009.001, <jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009&lt;\u2009.001, and <jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u2009.01, respectively). Sensitivity did not vary significantly with age. Among women with cancer, the proportion with invasive disease increased with age from 76% at ages 65 to 74 years to 81% at ages \u226580 years. There was a higher proportion of late stage cancers and positive lymph nodes among women ages 65 to 74 years compared with women in the older age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The specificity, PPV<jats:sub>1<\/jats:sub>, recall rate, and CDR of digital screening mammography improved with increased age. In addition, as age increased, the proportion of women with invasive versus ductal carcinoma in situ rose, whereas the proportion of women with positive lymph nodes decreased. <jats:bold><jats:italic>Cancer<\/jats:italic> 2015;121:1379\u20131386.<\/jats:bold> \u00a9 <jats:italic>2014 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.29214","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T10:54:00Z","timestamp":1419332040000},"page":"1379-1386","source":"Crossref","is-referenced-by-count":21,"title":["Performance of digital screening mammography among older women in the United States"],"prefix":"10.1002","volume":"121","author":[{"given":"Louise M.","family":"Henderson","sequence":"first","affiliation":[{"name":"Department of Radiology University of North Carolina Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen S.","family":"O'Meara","sequence":"additional","affiliation":[{"name":"Group Health Research Institute Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejana","family":"Braithwaite","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California at San Francisco San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Onega","sequence":"additional","affiliation":[{"name":"Department of Community and Family Medicine Geisel School of Medicine at Dartmouth Hanover New Hampshire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Breast Cancer Surveillance Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20138"},{"key":"e_1_2_7_3_1","volume-title":"Breast Cancer Facts & Figures 2013\u20102014","author":"American Cancer Society","year":"2013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.2079"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20096"},{"key":"e_1_2_7_6_1","first-page":"716","volume-title":"Ann Intern Med","author":"US Preventive Services Task Force","year":"2009"},{"key":"e_1_2_7_7_1","unstructured":"National Cancer Institute Breast Cancer Surveillance Consortium. 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