{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:29:18Z","timestamp":1789921758120,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T00:00:00Z","timestamp":1420675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2015,5,15]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Acne reflects hormone imbalance and is a key component of several systemic diseases. We hypothesized that diagnosis of acne as a teenager might predict subsequent risk of hormone\u2010related cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We followed 99,128 female nurses in the Nurses' Health Study II cohort for 20 years (1989\u20102009) and used Cox proportional hazards models to estimate the hazard ratios (HRs) of 8 specific cancers (breast, thyroid, colorectal, ovarian, cervical, and endometrial cancers, melanoma, and non\u2010Hodgkin lymphoma) for women with a history of severe teenage acne.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      After thoroughly adjusting for the previously known risk factors for each cancer, we found that among women with a history of severe teenage acne, the relative risk increased, with a multivariable\u2010adjusted HR of 1.44 (95% confidence interval [CI], 1.03\u20102.01) for melanoma. We replicated this association in an independent melanoma case\u2010control study of 930 cases and 1026 controls (multivariable\u2010adjusted odds ratio, 1.27; 95% CI, 1.03\u20101.56). We also found that in both studies the individuals with teenage acne were more likely to have moles (52.7% vs 50.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001 in the cohort study; and 55.2% vs 45.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.004 in the case\u2010control study).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Our findings suggest that a history of teenage acne might be a novel risk factor for melanoma independent from the known factors, which supports a need for continued investigation of these relationships.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2015;121:1681\u20131687\n                      <\/jats:bold>\n                      . \u00a9\n                      <jats:italic>2015 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.29216","type":"journal-article","created":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T15:24:12Z","timestamp":1420730652000},"page":"1681-1687","source":"Crossref","is-referenced-by-count":25,"title":["Teenage acne and cancer risk in US women: A prospective cohort study"],"prefix":"10.1002","volume":"121","author":[{"given":"Mingfeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology Brigham and Women's Hospital, and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abrar A.","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rhode Island Hospital,Warren Alpert Medical School Brown University Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e T.","family":"Fortner","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital, and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Hankinson","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital, and Harvard Medical School Boston Massachusetts"},{"name":"Department of Public Health School of Public Health and Health Sciences University of Massachusetts Amherst  Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyi","family":"Wei","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010E","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology The University of Texas, MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Heather","family":"Eliassen","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital, and Harvard Medical School Boston Massachusetts"},{"name":"Department of Epidemiology Harvard School of Public Health Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter C.","family":"Willett","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital, and Harvard Medical School Boston Massachusetts"},{"name":"Department of Epidemiology Harvard School of Public Health Boston Massachusetts"},{"name":"Department of Nutrition Harvard School of Public Health Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital, and Harvard Medical School Boston Massachusetts"},{"name":"Department of Epidemiology Harvard School of Public Health Boston Massachusetts"},{"name":"Department of Nutrition Harvard School of Public Health Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Richard M. Fairbanks School of Public Health Indiana University Indianapolis Indiana"},{"name":"Melvin and Bren Simon Cancer Center, Indiana University Indianapolis Indiana"},{"name":"Department of Dermatology School of Medicine Indiana University Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp033487"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2009.08.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.4290"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.3.427"},{"key":"e_1_2_8_6_1","first-page":"1466","article-title":"Hormone replacement therapy and risk of non\u2010hodgkin lymphoma and chronic lymphocytic leukemia","volume":"11","author":"Cerhan JR","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.7.11.7054"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03811.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq444"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91055-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23032"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-199610000-00004"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013796112348"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195309)6:5<870::AID-CNCR2820060505>3.0.CO;2-1"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/22.6.1000"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2009.1468"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1093\/oxfordjournals.aje.a114319","article-title":"Validation of questionnaire information on risk factors and disease outcomes in a prospective cohort study of women","volume":"123","author":"Colditz GA","year":"1886","journal-title":"Am J Epidemiol."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr415"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj376"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0976"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(82)90038-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840070628"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2011.05.002"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2307\/2344614"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-216-44153B"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1983.01650340009010"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12539043"},{"key":"e_1_2_8_28_1","first-page":"741085","article-title":"Hormonal influences on growth of B16 murine melanoma","author":"Simon SR","year":"1985","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340608783789185"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1983.tb07077.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1988.tb01780.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117361"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.098798"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200302000-00019"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1988"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgn243"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-78818-0_10"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001659"},{"key":"e_1_2_8_39_1","first-page":"4034","article-title":"The androgen receptor gene is preferentially hypermethylated in follicular non\u2010Hodgkin's lymphomas","volume":"9","author":"Yang H","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2413"},{"key":"e_1_2_8_41_1","volume-title":"Human Embryology and Teratology","author":"O'Rahilly R","year":"1992"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01286.x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010125"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm114"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.11.108"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr154"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.29216","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.29216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T15:30:46Z","timestamp":1760283046000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.29216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,8]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,5,15]]}},"alternative-id":["10.1002\/cncr.29216"],"URL":"https:\/\/doi.org\/10.1002\/cncr.29216","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725309544.793504305","asserted-by":"object"}]},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,8]]}}}