{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:18Z","timestamp":1786977498354,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Cancer Institute Cancer Center Support (CORE)","award":["CA-21765"],"award-info":[{"award-number":["CA-21765"]}]},{"DOI":"10.13039\/100007737","name":"St. Jude Children's Research Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007737","id-type":"DOI","asserted-by":"crossref"}]},{"name":"American Lebanese Syrian Associated Charities (ALSAC)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2015,7,15]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Partial nephrectomy is considered by some for children with unilateral Wilms tumor (UWT) to avoid the theoretical complication of renal insufficiency. In the current study, the authors evaluated the prevalence of hypertension and impaired renal function in long\u2010term survivors of nonsyndromic UWT who were treated without nephrotoxic chemotherapy or ionizing radiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Eligibility included age \u226415 years at the time of diagnosis of nonsyndromic UWT, treatment receipt before 2002, and maintenance of disease remission after unilateral nephrectomy without receipt of abdominal irradiation or nephrotoxic chemotherapy. Renal function was assessed by urinalysis and estimated glomerular filtration rate (eGFR). Patients receiving antihypertensive medication or those with blood pressure readings of &gt;140\/90 mm Hg were considered to be hypertensive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A total of 75 patients with a median age at diagnosis of 3.2 years (range, 0.2\u201012.1 years) met eligibility criteria. The median length of follow\u2010up was 19.6 years (range, 10.0\u201032.8 years). All but 1 patient had stage I\/II disease. Sixty\u2010eight patients (90.7%) patients had WT with favorable histology and 7 patients had anaplastic histology. Sixteen patients (21.3%) had an eGFR &lt;90 mL\/minute\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      , 2 of whom also had proteinuria (12.5%). No patient had an eGFR &lt;60 mL\/minute\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      . Five patients (6.7%) had hypertension, 3 of whom were receiving antihypertensive medications. At the time of last follow\u2010up, no patient had developed end\u2010stage renal disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Patients with UWT who were treated with unilateral radical nephrectomy without nephrotoxic chemotherapy or ionizing radiation appear to be at low risk of developing significant long\u2010term renal dysfunction. For this patient population, the routine use of partial nephrectomy does not appear justified. However, monitoring and counseling are important for identifying the rare patient who develops subtle renal insufficiency and therefore might be at an increased risk of adverse cardiovascular sequelae.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2015;121:2449\u20132456.\n                      <\/jats:bold>\n                      \u00a9\n                      <jats:italic>2015 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.29373","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T17:33:29Z","timestamp":1427996009000},"page":"2449-2456","source":"Crossref","is-referenced-by-count":60,"title":["Renal function in survivors of nonsyndromic Wilms tumor treated with unilateral radical nephrectomy"],"prefix":"10.1002","volume":"121","author":[{"given":"Rodrigo 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