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The authors examined the impact of beta\u2010adrenergic blockade on the clinical outcome of women with epithelial ovarian, primary peritoneal, or fallopian tube cancers (collectively, epithelial ovarian cancer [EOC]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A multicenter review of 1425 women with histopathologically confirmed EOC was performed. Comparisons were made between patients with documented beta\u2010blocker use during chemotherapy and those without beta\u2010blocker use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The median age of patients in the current study was 63 years (range, 21\u201093 years). The sample included 269 patients who received beta\u2010blockers. Of those, 193 (71.7%) were receiving beta\u20101\u2013adrenergic receptor selective agents, and the remaining patients were receiving nonselective beta antagonists. The primary indication for beta\u2010blocker use was hypertension but also included arrhythmia and postmyocardial infarction management. For patients receiving any beta\u2010blocker, the median overall survival (OS) was 47.8 months versus 42 months for nonusers (\n                      <jats:italic>P<\/jats:italic>\n                      =.04). The median OS based on beta\u2010blocker receptor selectivity was 94.9 months for those receiving nonselective beta\u2010blockers versus 38 months for those receiving beta\u20101\u2013adrenergic receptor selective agents (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001). Hypertension was associated with decreased OS compared with no hypertension across all groups. However, even among patients with hypertension, a longer median OS was observed among users of a nonselective beta\u2010blocker compared with nonusers (38.2 months vs 90 months;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Use of nonselective beta\u2010blockers in patients with EOC was associated with longer OS. These findings may have implications for new therapeutic approaches.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2015;121:3435\u201343.\n                      <\/jats:bold>\n                      \u00a9\n                      <jats:italic>2015 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.29392","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T13:06:58Z","timestamp":1440421618000},"page":"3444-3451","source":"Crossref","is-referenced-by-count":188,"title":["Clinical impact of selective and nonselective beta\u2010blockers on survival in patients with ovarian cancer"],"prefix":"10.1002","volume":"121","author":[{"given":"Jack L.","family":"Watkins","sequence":"first","affiliation":[{"name":"Department of Clinical Effectiveness The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premal H.","family":"Thaker","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpa M.","family":"Nick","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois M.","family":"Ramondetta","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology The Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana L.","family":"Urbauer","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Center, Department of Obstetrics and Gynecology Mercy Medical Center Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn C.","family":"Squires","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Coleman","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K.","family":"Lutgendorf","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Iowa Iowa City Iowa"},{"name":"Department of Obstetrics and Gynecology University of Iowa Iowa City Iowa"},{"name":"Department of Urology University of Iowa Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro T.","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston Texas"},{"name":"Department of Cancer Biology The University of Texas MD Anderson Cancer Center Houston Texas"},{"name":"Center for RNA Interference and Non\u2010Coding RNA Program, Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,24]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"4514","article-title":"Stress\u2010related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines","volume":"12","author":"Lutgendorf SK","year":"2003","journal-title":"Clin Cancer 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