{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:50:47Z","timestamp":1791899447665,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The National Heart, Lung, and Blood Institute of the National Institutes of Health","award":["CA018029"],"award-info":[{"award-number":["CA018029"]}]},{"name":"The National Heart, Lung, and Blood Institute of the National Institutes of Health","award":["CA15704"],"award-info":[{"award-number":["CA15704"]}]},{"name":"The National Heart, Lung, and Blood Institute of the National Institutes of Health","award":["CA078902"],"award-info":[{"award-number":["CA078902"]}]},{"name":"The National Heart, Lung, and Blood Institute of the National Institutes of Health","award":["HL088021"],"award-info":[{"award-number":["HL088021"]}]},{"name":"The National Heart, Lung, and Blood Institute of the National Institutes of Health","award":["5T32HL007093-38"],"award-info":[{"award-number":["5T32HL007093-38"]}]},{"name":"Mohamed L. Sorror is also supported by a Research Scholar Grant from the American Cancer Society","award":["RSG-13-084-01-CPHPS"],"award-info":[{"award-number":["RSG-13-084-01-CPHPS"]}]},{"name":"The Patient-Centered Outcomes Research Institute","award":["CE-1304-7451"],"award-info":[{"award-number":["CE-1304-7451"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2015,10,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Previously, early results were reported for allogeneic hematopoietic cell transplantation (HCT) after nonmyeloablative conditioning with 2 Gy of total body irradiation with or without fludarabine and\/or rituximab in 33 patients with mantle cell lymphoma (MCL).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This study examined the outcomes of 70 patients with MCL and included extended follow\u2010up (median, 10 years) for the 33 initial patients. Grafts were obtained from human leukocyte antigen (HLA)\u2013matched, related donors (47%), unrelated donors (41%), and HLA antigen\u2013mismatched donors (11%).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The 5\u2010year incidence of nonrelapse mortality was 28%. The relapse rate was 26%. The 5\u2010year rates of overall survival (OS) and progression\u2010free survival (PFS) were 55% and 46%, respectively. The 10\u2010year rates of OS and PFS were 44% and 41%, respectively. Eighty percent of surviving patients were off immunosuppression at the last follow\u2010up. The presence of relapsed or refractory disease at the time of HCT predicted a higher rate of relapse (hazard ratio [HR], 2.94; <jats:italic>P<\/jats:italic> = .05). Despite this, OS rates at 5 (51% vs 58%) and 10 years (43% vs 45%) were comparable between those with relapsed\/refractory disease and those undergoing transplantation with partial or complete remission. A high\u2010risk cytomegalovirus (CMV) status was the only independent predictor of worse OS (HR, 2.32; <jats:italic>P<\/jats:italic> = .02). A high\u2010risk CMV status and a low CD3 dose predicted PFS (HR, 2.22; <jats:italic>P<\/jats:italic> = .03).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Nonmyeloablative allogeneic HCT provides a long\u2010term survival benefit for patients with relapsed MCL, including those with refractory disease or multiple relapses. <jats:bold><jats:italic>Cancer<\/jats:italic> 2015;121:3709\u20133716<\/jats:bold>. \u00a9 <jats:italic>2015 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.29498","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T09:41:17Z","timestamp":1437730877000},"page":"3709-3716","source":"Crossref","is-referenced-by-count":32,"title":["Long\u2010term sustained disease control in patients with mantle cell lymphoma with or without active disease after treatment with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning"],"prefix":"10.1002","volume":"121","author":[{"given":"Jennifer E.","family":"Vaughn","sequence":"first","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington"},{"name":"Division of Medical Oncology Department of Medicine University of Washington School of Medicine Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed L.","family":"Sorror","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington"},{"name":"Division of Medical Oncology Department of Medicine University of Washington School of Medicine Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry E.","family":"Storer","sequence":"additional","affiliation":[{"name":"Clinical Statistics Program Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington"},{"name":"Department of Biostatistics University of Washington School of Public Health Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Chauncey","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington"},{"name":"Division of Medical Oncology Department of Medicine University of Washington School of Medicine Seattle Washington"},{"name":"Marrow Transplant Unit VA Puget Sound Health Care System Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Pulsipher","sequence":"additional","affiliation":[{"name":"Pediatric Blood and Marrow Transplant Program Primary Children's Hospital Salt Lake City Utah"},{"name":"Division of Hematology\/Hematological Malignancies Huntsman Cancer Institute University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T.","family":"Maziarz","sequence":"additional","affiliation":[{"name":"Center for Hematologic Malignancies Knight Cancer Institute Oregon Health and Science University Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Maris","sequence":"additional","affiliation":[{"name":"Colorado Blood Cancer Institute Denver Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parameswaran","family":"Hari","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginna G.","family":"Laport","sequence":"additional","affiliation":[{"name":"Division of Blood and Marrow Transplantation Department of Medicine Stanford School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg N.","family":"Franke","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology and Hemostaseology Department of Medicine University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward D.","family":"Agura","sequence":"additional","affiliation":[{"name":"Hematopoietic Stem Cell Program Baylor University School of Medicine Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia A.","family":"Langston","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Emory University School of Medicine Atlanta Georgia"},{"name":"Bone Marrow &amp; Stem Cell Transplant Center Winship Cancer Institute Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Rezvani","sequence":"additional","affiliation":[{"name":"Division of Blood and Marrow Transplantation Department of Medicine Stanford School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Storb","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington"},{"name":"Division of Medical Oncology Department of Medicine University of Washington School of Medicine Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda M.","family":"Sandmaier","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington"},{"name":"Division of Medical Oncology Department of Medicine University of Washington School of Medicine Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Maloney","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington"},{"name":"Division of Medical Oncology Department of 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