{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:41:10Z","timestamp":1765960870690,"version":"build-2065373602"},"reference-count":13,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2015,12,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Characterizing the role of postchemotherapy retroperitoneal lymph node dissection (PC\u2010RPLND) after high\u2010dose chemotherapy (HDCT) has been limited by small sample sizes. This study reports on survival after HDCT with stem cell support and PC\u2010RPLND as well as histologic findings in the retroperitoneum.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The prospectively maintained testicular cancer database of Indiana University was queried for patients receiving HDCT with stem cell transplantation before PC\u2010RPLND. The cause and date of death were obtained through patient chart review and contact with referring physicians. The Kaplan\u2010Meier method was used to evaluate overall survival (OS). The log\u2010rank test was used for tests of significance. A multivariate, backward, stepwise Cox regression model was built to evaluate predictors of overall mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 92 patients were included in the study. In the entire cohort, the retroperitoneal (RP) histology findings at the time of PC\u2010RPLND were necrosis (26%), teratoma (34%), and cancer (38%). Sixty\u2010six patients (72%) harbored either a teratoma or active cancer in the RP specimen at PC\u2010RPLND. The median follow\u2010up for the entire cohort was 80.6 months. A total of 28 patients (30%) died during follow\u2010up. The 5\u2010year OS rate of the entire cohort was 70%. The most significant predictor of death was PC\u2010RPLND performed in the desperation setting with elevated markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Despite these patients being heavily pretreated with multiple cycles of chemotherapy, including HDCT, approximately three\u2010fourths were found to have a teratoma and\/or active cancer in the retroperitoneum. This underscores the importance of PC\u2010RPLND for rendering patients free of disease and providing a potential for cure. <jats:bold><jats:italic>Cancer<\/jats:italic> 2015;121:4369\u201375.<\/jats:bold> \u00a9 <jats:italic>2015 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.29678","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T14:31:09Z","timestamp":1442327469000},"page":"4369-4375","source":"Crossref","is-referenced-by-count":20,"title":["Outcomes of postchemotherapy retroperitoneal lymph node dissection following high\u2010dose chemotherapy with stem cell transplantation"],"prefix":"10.1002","volume":"121","author":[{"given":"Clint","family":"Cary","sequence":"first","affiliation":[{"name":"Department of Urology Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A.","family":"Pedrosa","sequence":"additional","affiliation":[{"name":"Department of Urology Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of Urology Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen D. 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