{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:15:46Z","timestamp":1777418146683,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T00:00:00Z","timestamp":1444176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>In Chile, mortality from colorectal cancer (CRC) has increased rapidly. To help address this issue, the Prevention Project for Neoplasia of the Colon and Rectum (PRENEC) program was initiated in 2012 with intensive support from Tokyo Medical and Dental University (TMDU) in Tokyo, Japan, as part of an international collaboration.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>From June 2012 to July 2014, a total of 10,575 asymptomatic participants were enrolled in PRENEC. Participants with positive immunochemical fecal occult blood test (iFOBT) results or a family history of CRC underwent colonoscopy. The colonoscopy results from a similar, previous project in Chile (PREVICOLON) were compared with those from PRENEC. Furthermore, the initial colonoscopies of 1562 participants in PRENEC were analyzed according to whether the colonoscopists were from TMDU or Chile.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The complete colonoscopy, adenoma detection, and cancer detection rates were 88.0%, 26.7%, and 1.1%, respectively, in PREVICOLON, while the corresponding values were 94.4%, 41.8%, and 6.0%, respectively, in PRENEC. In PRENEC, 107 cases of CRC were detected, amounting for 1.0% of all participants. Considering initial colonoscopies in PRENEC, the complete colonoscopy, adenoma detection, and cancer detection rates were 97.4%, 45.3%, and 9.3%, respectively, for physicians at TMDU and 93.3%, 41.5%, and 5.1%, respectively for Chilean physicians. The detection rates of intramucosal cancer were 7.3% and 3.7%, respectively, for TMDU and Chilean physicians.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Quality indicators of colonoscopy substantially improved from PREVICOLON to PRENEC. The assessments made by Chilean physicians alone were improved in PRENEC, but remained better in the TMDU group. Moreover, physicians from TMDU detected more CRCs than Chilean physicians, especially at earlier stages. <jats:bold><jats:italic>Cancer<\/jats:italic> 2016;122:71\u201377.<\/jats:bold> \u00a9 <jats:italic>2015 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.29715","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T17:29:47Z","timestamp":1444238987000},"page":"71-77","source":"Crossref","is-referenced-by-count":19,"title":["International collaboration between Japan and Chile to improve detection rates in colorectal cancer screening"],"prefix":"10.1002","volume":"122","author":[{"given":"Takuya","family":"Okada","sequence":"first","affiliation":[{"name":"Latin American Collaborative Research Center of Tokyo Medical and Dental University Santiago Chile"},{"name":"Department of Digestive and General Surgery Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Latin American Collaborative Research Center of Tokyo Medical and Dental University Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kawachi","sequence":"additional","affiliation":[{"name":"Latin American Collaborative Research Center of Tokyo Medical and Dental University Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ito","sequence":"additional","affiliation":[{"name":"Latin American Collaborative Research Center of Tokyo Medical and Dental University Santiago Chile"},{"name":"Department of Human Pathology Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Nishikage","sequence":"additional","affiliation":[{"name":"Latin American Collaborative Research Center of Tokyo Medical and Dental University Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Odagaki","sequence":"additional","affiliation":[{"name":"Latin American Collaborative Research Center of Tokyo Medical and Dental University Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro J","family":"Z\u00e1rate","sequence":"additional","affiliation":[{"name":"Unit of Coloproctology Las Condes Clinic Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udo","family":"Kronberg","sequence":"additional","affiliation":[{"name":"Unit of Coloproctology Las Condes Clinic Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"L\u00f3pez\u2010K\u00f6stner","sequence":"additional","affiliation":[{"name":"Unit of Coloproctology Las Condes Clinic Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanko","family":"Karelovic","sequence":"additional","affiliation":[{"name":"Department of Digestive Endoscopy, Magallanes Hospital Punta Arenas Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Flores","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dr. Eduardo Pereira Hospital Valparaiso Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Estela","sequence":"additional","affiliation":[{"name":"Chilean\u2010Japanese Institute for Digestive Diseases, San Borja Arriaran Hospital Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Tsubaki","sequence":"additional","affiliation":[{"name":"Latin American Collaborative Research Center of Tokyo Medical and Dental University Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Uetake","sequence":"additional","affiliation":[{"name":"Department of Digestive and General Surgery Tokyo Medical and Dental University Tokyo Japan"},{"name":"Department of Surgical Specialties Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Eishi","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuyuki","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Digestive and General Surgery Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2012.03110.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.5.434"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)03386-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)03430-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312303292701"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.6.812"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1100370"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.040"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.090845"},{"key":"e_1_2_7_13_1","first-page":"281","article-title":"A screening program for colorectal cancer in Chilean subjects aged fifty years or more [in Spanish]","volume":"140","author":"Lopez\u2010Kostner F","year":"2012","journal-title":"Rev Med Chil."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-945196"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907667"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1309086"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/172460080602100304"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jms.9.3.99"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200610000-00002"},{"key":"e_1_2_7_20_1","volume-title":"TNM Classification of Malignant Tumours","author":"Sobin LH","year":"2009"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2012.01252.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.05.057"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-009-0515-1"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.12.012"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-010-0650-8"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011303432203"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(03)02159-X"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-995618"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.9.1027"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.02.062"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8898630"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001101)89:9<1901::AID-CNCR5>3.0.CO;2-#"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(05)80003-3"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055498"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03080.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.04.018"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(00)70383-X"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.29715","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.29715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T14:12:53Z","timestamp":1760278373000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.29715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,7]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1002\/cncr.29715"],"URL":"https:\/\/doi.org\/10.1002\/cncr.29715","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,7]]}}}