{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:23:08Z","timestamp":1792801388556,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"crossref","award":["1\u2009R01 NR014182-01"],"award-info":[{"award-number":["1\u2009R01 NR014182-01"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"crossref","award":["T32-NS047987"],"award-info":[{"award-number":["T32-NS047987"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ortho Biotech"},{"name":"The Lynn Sage Cancer Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,1,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Patients who receive adjuvant chemotherapy have reported cognitive impairments that may last for years after the completion of treatment. Working memory\u2010related and long\u2010term memory\u2010related changes in this population are not well understood. The objective of this study was to demonstrate that cancer\u2010related cognitive impairments are associated with the under recruitment of brain regions involved in working and recognition memory compared with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Oncology patients (n\u2009=\u200915) who were receiving adjuvant chemotherapy and had evidence of cognitive impairment according to neuropsychological testing and self\u2010report and a group of age\u2010matched, education group\u2010matched, cognitively normal control participants (n\u2009=\u200914) underwent functional magnetic resonance imaging. During functional magnetic resonance imaging, participants performed a nonverbal n\u2010back working memory task and a visual recognition task.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>On the working memory task, when 1\u2010back and 2\u2010back data were averaged and contrasted with 0\u2010back data, significantly reduced activation was observed in the right dorsolateral prefrontal cortex for oncology patients versus controls. On the recognition task, oncology patients displayed decreased activity of the left\u2010middle hippocampus compared with controls. Neuroimaging results were not associated with patient\u2010reported cognition.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Decreased recruitment of brain regions associated with the encoding of working memory and recognition memory was observed in the oncology patients compared with the control group. These results suggest that there is a reduction in neural functioning postchemotherapy and corroborate patient\u2010reported cognitive difficulties after cancer treatment, although a direct association was not observed. <jats:bold><jats:italic>Cancer<\/jats:italic> 2016;122:258\u2013268.<\/jats:bold> \u00a9 <jats:italic>2015 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.29737","type":"journal-article","created":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T20:40:19Z","timestamp":1445460019000},"page":"258-268","source":"Crossref","is-referenced-by-count":34,"title":["Reduced prefrontal activation during working and long\u2010term memory tasks and impaired patient\u2010reported cognition among cancer survivors postchemotherapy compared with healthy controls"],"prefix":"10.1002","volume":"122","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Clinical Psychology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"},{"name":"Department of Psychiatry and Behavioral Sciences Northwestern University Feinberg School of Medicine, Chicago, Illinois"},{"name":"Department of Radiology Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra C.","family":"Apple","sequence":"additional","affiliation":[{"name":"Division of Clinical Psychology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"},{"name":"Department of Psychiatry and Behavioral Sciences Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Schroeder","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony 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