{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:09:58Z","timestamp":1790662198785,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T00:00:00Z","timestamp":1450137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Patients with myeloproliferative neoplasms (MPNs) experience a high persistence, prevalence, and severity of fatigue. There is currently only limited information regarding factors that contribute to fatigue in patients with MPNs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A 70\u2010item, Internet\u2010based survey regarding fatigue was developed by MPN investigators and patients\/advocates and hosted by the Mayo Clinic Survey Research Center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Fatigue was found to be prevalent and severe among international survey respondents (1788 respondents). Higher body mass index (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001), current use of alcohol (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001), and current tobacco use (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.0025) were found to be significantly associated with greater fatigue. Moderate\/severe fatigue was present more frequently in those individuals who did not exercise compared with those who reported exercising at least once per week (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001). Medical comorbidities found to be significantly associated with greater fatigue included restless leg syndrome (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.006), diabetes mellitus (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.045), fibromyalgia (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), chronic fatigue syndrome (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.006), and chronic kidney disease (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.02). Current use of antidepressants (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001), antihistamines (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.0276), antianxiety medications (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.0357), and prescription pain medications (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001) were found to be associated with worsened fatigue. Nearly 25% of respondents scored\u2009&gt;\u20092 on the Patient Health Questionnaire, indicating a high probability of depression. Higher Brief Fatigue Inventory score, Myeloproliferative Neoplasm Total Symptom Score, and individual symptom items were all associated with a higher likelihood of depressive symptoms (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      The management of fatigue should be multifactorial, with a comprehensive assessment and treatment plan to address all modifiable fatigue etiologies. Patients with MPNs likely have a higher prevalence of mood disturbances compared with the general population, suggesting the need to assess and intervene in this domain.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2016;122:477\u2013485.\n                      <\/jats:bold>\n                      \u00a9\n                      <jats:italic>2015 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.29753","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T19:53:51Z","timestamp":1450209231000},"page":"477-485","source":"Crossref","is-referenced-by-count":59,"title":["Comprehensively understanding fatigue in patients with myeloproliferative neoplasms"],"prefix":"10.1002","volume":"122","author":[{"given":"Robyn M.","family":"Scherber","sequence":"first","affiliation":[{"name":"Division 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