{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:28Z","timestamp":1786977388603,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T00:00:00Z","timestamp":1445212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>After a pilot study on skin cancer screening was performed between 2003 and 2004 in Schleswig\u2010Holstein, Germany, the country implemented what to the authors' knowledge is the first nationwide skin cancer screening program in the world in 2008. The objective of the current study was to provide details regarding mortality trends in Schleswig\u2010Holstein and Germany in relation to the screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Annual age\u2010standardized mortality rates for skin melanoma (using the\n                      <jats:italic>10th Revision of the International Statistical Classification of Diseases and Related Health Problems<\/jats:italic>\n                      [ICD\u201010] code C43) and malignant neoplasms of ill\u2010defined, secondary, and unspecified sites (ICD\u201010 code C76\u2010C80) were analyzed. The European Standard population was used for age standardization. A bias analysis was performed to estimate the number of skin melanoma deaths that may have been incorrectly counted as ICD\u201010 code C76\u2010C80 when the skin melanoma mortality declined in Schleswig\u2010Holstein.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The observed mortality decline in Schleswig\u2010Holstein 5 years after the pilot study was accompanied by a considerable increase in the number of deaths due to malignant neoplasms of ill\u2010defined, secondary, and unspecified sites (ICD\u201010 code C76\u2010C80) that is not explainable by an increase in the incidence of these neoplasms. Incorrect assignment of 8 to 35 and 12 to 23 skin melanoma deaths per year among men and women, respectively, as ICD\u201010 code C76\u2010C80 during 2007 through 2010 could explain the transient skin melanoma mortality decline observed in Schleswig\u2010Holstein. Five years after implementation of the program, the nationwide skin melanoma mortality increased (age\u2010standardized rate change of +0.4 per 100,000 person\u2010years [95% confidence interval, 0.2\u20100.6] in men and +0.1 per 100,000 person\u2010years [95% confidence interval, \u20100.1 to 0.2] in women).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Although the current analyses raise doubts that the skin cancer screening program in Germany can reduce the skin cancer mortality rate, the authors do not believe the program should be immediately stopped. Further in\u2010depth evaluations are required.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2016;122:432\u2013437.\n                      <\/jats:bold>\n                      \u00a9\n                      <jats:italic>2015 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.29755","type":"journal-article","created":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T11:55:20Z","timestamp":1445255720000},"page":"432-437","source":"Crossref","is-referenced-by-count":77,"title":["Does skin cancer screening save lives? A detailed analysis of mortality time trends in Schleswig\u2010Holstein and Germany"],"prefix":"10.1002","volume":"122","author":[{"given":"Andreas","family":"Stang","sequence":"first","affiliation":[{"name":"Center of Clinical Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology University Hospital of Essen Essen Germany"},{"name":"Department of Epidemiology, School of Public Health Boston University Boston Massachusetts"},{"name":"German Consortium for Translational Cancer Research (DKTK) Heidelberg Germany"},{"name":"Institute of Medical Informatics, Biometry and Epidemiology University Hospital of Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl\u2010Heinz","family":"J\u00f6ckel","sequence":"additional","affiliation":[{"name":"German Consortium for Translational Cancer Research (DKTK) Heidelberg Germany"},{"name":"Institute of Medical Informatics, Biometry and Epidemiology University Hospital of Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11091.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27566"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000364887"},{"key":"e_1_2_7_5_1","unstructured":"VeitC LukenF MelsheimerO.Evaluation of the skin cancer screening according to the screening guideline of the common federal committee. Abschlussbericht 2009\u20102010. BQS Institut fur Qualitat und Patientensicherheit GmbH;2015."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(03)00002-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2004.05831.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.01.056"},{"key":"e_1_2_7_9_1","volume-title":"International Statistical Classification of Diseases and Related Health Problems. 10th Rev","author":"World Health Organization","year":"1992"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910020310"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009607"},{"key":"e_1_2_7_12_1","first-page":"575","article-title":"The post mortem external examination: determination of the cause and manner of death","volume":"107","author":"Madea B","year":"2010","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00052751"},{"key":"e_1_2_7_14_1","volume-title":"Data and facts: results of the study \u201cHealth in Germany 2010\u201d","author":"Robert Koch\u2010Institut","year":"2012"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00103-012-1655-4"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.29755","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.29755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T14:18:06Z","timestamp":1760278686000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.29755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,19]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1002\/cncr.29755"],"URL":"https:\/\/doi.org\/10.1002\/cncr.29755","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,19]]}}}