{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:24:14Z","timestamp":1782257054326,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T00:00:00Z","timestamp":1446681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>Medullary thyroid carcinoma (MTC) is a neuroendocrine malignancy of the thyroid C cells that occurs in hereditary and sporadic clinical settings. Metastatic spread commonly occurs to cervical and mediastinal lymph nodes. MTC cells do not concentrate radioactive iodine and are not sensitive to hormonal manipulation, and therefore surgery is the most effective option for curative therapy, reduction in tumor burden, or effective palliation. In patients undergoing preventative surgery for hereditary MTC, central lymph node dissection should be considered if the calcitonin level is elevated. Preservation of parathyroid function in these young patients is of paramount importance. In patients with established primary tumors, systematic surgical removal of lymph node basins (compartmental dissection) should be guided by ultrasound mapping of lymph node metastases and level of serum calcitonin. A \u201cberry\u2010picking\u201d approach is discouraged. Newly approved targeted molecular therapies offer wider treatment options for patients with progressive or metastatic disease. <jats:bold><jats:italic>Cancer<\/jats:italic> 2016;122:358\u2013366.<\/jats:bold> \u00a9 <jats:italic>2015 American Cancer Society<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/cncr.29761","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T11:28:50Z","timestamp":1446722930000},"page":"358-366","source":"Crossref","is-referenced-by-count":49,"title":["Surgery for lymph node metastases of medullary thyroid carcinoma: A review"],"prefix":"10.1002","volume":"122","author":[{"given":"Linda X.","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Surgery Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey F.","family":"Moley","sequence":"additional","affiliation":[{"name":"Section of Endocrine and Oncologic Surgery, Department of Surgery, Siteman Cancer Center Washington University School of Medicine St. Louis Missouri"},{"name":"Department of Surgery St. Louis Veterans Affairs Medical Center St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,5]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981215)83:12<2638::AID-CNCR31>3.0.CO;2-1"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0335"},{"key":"e_1_2_4_4_1","first-page":"37","article-title":"Long\u2010term survival in sporadic and familial medullary thyroid carcinoma with special reference to clinical characteristics as prognostic factors. The Swedish MTC Study Group","volume":"156","author":"Bergholm U","year":"1990","journal-title":"Acta Chir Scand"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000301)88:5<1139::AID-CNCR26>3.0.CO;2-Z"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-007-9185-1"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1836"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20690"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960415)77:8<1556::AID-CNCR20>3.0.CO;2-Y"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03229.x"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0194-70"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.7.851"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870120308"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7824936"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012915"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0039-6060(03)00157-0"},{"key":"e_1_2_4_17_1","first-page":"1070","article-title":"Prevalence of pheochromocytoma and hyperparathyroidism in multiple endocrine neoplasia type 2A: results of long\u2010term follow\u2010up","volume":"114","author":"Howe JR","year":"1993","journal-title":"Surgery"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.1.380"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0857-5_17"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200205000-00006"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-007-9317-7"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.12.8070"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03540190047028"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.02160.x"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199906000-00016"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02473391"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900124"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900463"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043999"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199605000-00003"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)41742-1"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2388(199901\/02)16:1<50::AID-SSU9>3.0.CO;2-6"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351148"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2368"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6075"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(05)80120-5"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409293311302"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199409000-00002"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2757-9"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9036-6"},{"key":"e_1_2_4_41_1","first-page":"1017","article-title":"Medullary thyroid carcinoma in multiple endocrine neoplasia types 2A and 2B","volume":"116","author":"O'Riordain DS","year":"1994","journal-title":"Surgery"},{"key":"e_1_2_4_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(05)80109-6"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900435"},{"key":"e_1_2_4_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(97)90217-8"},{"key":"e_1_2_4_45_1","first-page":"60","article-title":"Reoperation in the treatment of asymptomatic metastasizing medullary thyroid carcinoma","volume":"99","author":"Tisell LE","year":"1986","journal-title":"Surgery"},{"key":"e_1_2_4_46_1","first-page":"1090","article-title":"Reoperation for recurrent or persistent medullary thyroid cancer","volume":"114","author":"Moley JF","year":"1993","journal-title":"Surgery"},{"key":"e_1_2_4_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1978.01370160026003"},{"key":"e_1_2_4_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199706000-00011"},{"key":"e_1_2_4_49_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1211"},{"key":"e_1_2_4_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03666.x"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.29761","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.29761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T14:18:23Z","timestamp":1760278703000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.29761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,5]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1002\/cncr.29761"],"URL":"https:\/\/doi.org\/10.1002\/cncr.29761","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,5]]}}}