{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:59:06Z","timestamp":1790251146276,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T00:00:00Z","timestamp":1446681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ClinicalTrials.gov","award":["NCT01389414"],"award-info":[{"award-number":["NCT01389414"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,2,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Biliary tract cancer (BTC) is a rare and lethal disease with few therapeutic options. Preclinical data suggest that the epidermal growth factor receptor (EGFR) pathway could be involved in its progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This open\u2010label, randomized phase 2 trial recruited chemotherapy\u2010naive patients with advanced BTC displaying a wild\u2010type (WT) <jats:italic>KRAS<\/jats:italic> status. Patients were randomized to gemcitabine (1000\u2009mg\/m<jats:sup>2<\/jats:sup>) and oxaliplatin (100\u2009mg\/m<jats:sup>2<\/jats:sup>) with (arm A) or without (arm B) panitumumab (6\u2009mg\/kg) for up to 12 cycles. The primary endpoint was progression\u2010free survival (PFS) analyzed in an intention\u2010to\u2010treat fashion.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Eighty\u2010nine patients (45 in arm A and 44 in arm B) were enrolled between June 2010 and September 2013. After a median follow\u2010up of 10.1 months, the median PFS was 5.3 months (95% confidence interval, 3.3\u20107.2 months) in arm A and 4.4 months (95% confidence interval, 2.6\u20106.2 months) in arm B (<jats:italic>P<\/jats:italic>\u2009=\u2009.27). No survival differences were observed: the median overall survival was 9.9 months in arm A and 10.2 months in arm B (<jats:italic>P<\/jats:italic>\u2009=\u2009.42). In a subgroup analysis, no differences in PFS according to the site of the primary tumor were observed; patients with intrahepatic cholangiocarcinoma treated with panitumumab may have had a survival benefit in comparison with the control group (15.1 vs 11.8 months, <jats:italic>P<\/jats:italic>\u2009=\u2009.13). As for safety, skin toxicity was the main adverse event in arm A (80% of the patients). A higher incidence of diarrhea (55.5% vs 31.8%), mucositis (22.2% vs 13.6%), and constipation (24.4% vs 15.9%) was seen in arm A.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>These results confirm the marginal role of anti\u2010EGFR therapy even for WT <jats:italic>KRAS\u2013<\/jats:italic>selected BTC. <jats:bold><jats:italic>Cancer<\/jats:italic> 2016;122:574\u2013581.<\/jats:bold> \u00a9 <jats:italic>2015 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.29778","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T11:28:43Z","timestamp":1446722923000},"page":"574-581","source":"Crossref","is-referenced-by-count":126,"title":["Panitumumab in combination with gemcitabine and oxaliplatin does not prolong survival in wild\u2010type <scp><i>KRAS<\/i><\/scp> advanced biliary tract cancer: A randomized phase 2 trial (<scp>V<\/scp>ecti\u2010<scp>BIL<\/scp> study)"],"prefix":"10.1002","volume":"122","author":[{"given":"Francesco","family":"Leone","sequence":"first","affiliation":[{"name":"Department of Oncology University of Turin Medical School\/Piedmont Foundation for Oncology, Candiolo Cancer Institute \u2010 FPO, IRCCS Candiolo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Oncology University of Turin Medical School\/Piedmont Foundation for Oncology, Candiolo Cancer Institute \u2010 FPO, IRCCS Candiolo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Cereda","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology San Raffaele Scientific Institute, IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Filippi","sequence":"additional","affiliation":[{"name":"Department of Oncology University of Turin Medical School\/Piedmont Foundation for Oncology, Candiolo Cancer Institute \u2010 FPO, IRCCS Candiolo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Belli","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology San Raffaele Scientific Institute, IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosella","family":"Spadi","sequence":"additional","affiliation":[{"name":"Department of Oncology, Medical Oncology 1 Division Citt\u00e0 Della Salute e Della Scienza Hospital and University Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guglielmo","family":"Nasti","sequence":"additional","affiliation":[{"name":"Department of Colorectal Oncology National Cancer Institute G. Pascale Foundation Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Montano","sequence":"additional","affiliation":[{"name":"Department of Colorectal Oncology National Cancer Institute G. Pascale Foundation Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Amatu","sequence":"additional","affiliation":[{"name":"Niguarda Cancer Center, Niguarda Ca' Granda Hospita Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Aprile","sequence":"additional","affiliation":[{"name":"Department of Oncology University and General Hospital Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste","family":"Cagnazzo","sequence":"additional","affiliation":[{"name":"Department of Oncology University of Turin Medical School\/Piedmont Foundation for Oncology, Candiolo Cancer Institute \u2010 FPO, IRCCS Candiolo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpiero","family":"Fasola","sequence":"additional","affiliation":[{"name":"Department of Oncology University and General Hospital Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Siena","sequence":"additional","affiliation":[{"name":"Niguarda Cancer Center, Niguarda Ca' Granda Hospita Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libero","family":"Ciuffreda","sequence":"additional","affiliation":[{"name":"Department of Oncology, Medical Oncology 1 Division Citt\u00e0 Della Salute e Della Scienza Hospital and University Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Reni","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology San Raffaele Scientific Institute, IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Aglietta","sequence":"additional","affiliation":[{"name":"Department of Oncology University of Turin Medical School\/Piedmont Foundation for Oncology, Candiolo Cancer Institute \u2010 FPO, IRCCS Candiolo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13651820801992641"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3182703409"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908721"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.3605"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2012.06.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1692"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1779"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70247-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh351"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28223"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.07.143"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt337"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt416"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.343"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70212-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv035"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70301-1"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.29778","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.29778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:42:55Z","timestamp":1760272975000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.29778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,5]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,2,15]]}},"alternative-id":["10.1002\/cncr.29778"],"URL":"https:\/\/doi.org\/10.1002\/cncr.29778","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,5]]}}}