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The reported prevalence of ototoxicity in patients who have received potentially ototoxic therapy ranges from 4% to 90% depending on factors such as age of the patient population, agent(s) used, cumulative dose, and administration techniques. The impact of ototoxicity on subsequent health\u2010related and psychosocial outcomes in these patients can be substantial, and the burden of morbidity related to ototoxic agents is particularly high in very young children. Considerable interindividual variability in the prevalence and severity of ototoxicity has been observed among patients receiving similar treatment, suggesting genetic susceptibility as a risk factor. The development and testing of otoprotective agents is ongoing; however, to the author's knowledge, no US Food and Drug Administration\u2010approved otoprotectants are currently available. Prospective monitoring for ototoxicity allows for comparison of auditory outcomes across clinical trials, as well as for early detection, potential alterations in therapy, and auditory intervention and rehabilitation to ameliorate the adverse consequences of hearing loss. <jats:bold><jats:italic>Cancer<\/jats:italic> 2016;122:1647\u201058<\/jats:bold>. \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/cncr.29779","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T12:26:49Z","timestamp":1455020809000},"page":"1647-1658","source":"Crossref","is-referenced-by-count":188,"title":["Ototoxicity and cancer therapy"],"prefix":"10.1002","volume":"122","author":[{"given":"Wendy","family":"Landier","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,9]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000199586.98926.8e"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.2038"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.00.5355"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21875"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2012.997"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.6.754"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31815d1d83"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.226"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199607)27:1<26::AID-MPO6>3.0.CO;2-W"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.0096"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23275"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31821f0eaf"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1081\/CNV-200055951"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2003.08.009"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.1110"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju044"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0659"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.11.48"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111001002"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.11.047"},{"key":"e_1_2_4_22_1","first-page":"173","volume-title":"Management of Head and Neck Cancer. 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