{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:36:24Z","timestamp":1791203784754,"version":"4.2.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T00:00:00Z","timestamp":1447372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,2,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Double\u2010hit lymphomas (DHLs) are collectively defined as B\u2010cell non\u2010Hodgkin lymphomas harboring rearrangements of <jats:italic>MYC<\/jats:italic> as well as B\u2010cell lymphoma 2 (<jats:italic>BCL2<\/jats:italic>) and\/or B\u2010cell lymphoma 6 (<jats:italic>BCL6<\/jats:italic>). To the authors' knowledge, the impact of specific oncogene rearrangements on outcomes of patients with DHL who are treated with immunochemotherapy has not been previously described.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors identified patients whose diagnostic tissue specimens underwent metaphase karyotyping or fluorescence in situ hybridization for <jats:italic>MYC<\/jats:italic> as well as both <jats:italic>BCL2<\/jats:italic> and <jats:italic>BCL6<\/jats:italic> rearrangements. Cohorts were defined by the presence (+) or absence (\u2212) of rearrangements: <jats:italic>MYC<\/jats:italic>+\/<jats:italic>BCL2<\/jats:italic>+\/<jats:italic>BCL6<\/jats:italic>\u2212 (BCL2\u2010DHL), <jats:italic>MYC<\/jats:italic>+\/<jats:italic>BCL2<\/jats:italic>\u2212\/<jats:italic>BCL6+<\/jats:italic> (BCL6\u2010DHL), and <jats:italic>MYC<\/jats:italic>+\/<jats:italic>BCL2<\/jats:italic>+\/<jats:italic>BCL6<\/jats:italic>+ (triple\u2010hit lymphoma; THL).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 117 patients were included in the current analysis (76 BCL2\u2010DHL patients, 16 BCL6\u2010DHL patients, and 25 THL patients). Compared with patients with BCL2\u2010DHL, those with BCL6\u2010DHL were more likely to be classified as having a non\u2010germinal center cell of origin, presented with extranodal disease, and appeared to achieve higher rates of complete response despite receiving intensive induction therapy less frequently. However, patients with BCL6\u2010DHL experienced a shorter median overall survival if achieving an initial complete response compared with patients with BCL2\u2010DHL. Patients with THL experienced survival outcomes similar to those of patients with BCL2\u2010DHL.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Recognition of the specific oncogene rearrangements may be of prognostic value and potentially guide future therapeutic strategies for patients with DHL. <jats:bold><jats:italic>Cancer<\/jats:italic> 2016;122:559\u2013564.<\/jats:bold> \u00a9 <jats:italic>2015 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.29781","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T11:23:22Z","timestamp":1447413802000},"page":"559-564","source":"Crossref","is-referenced-by-count":77,"title":["Impact of oncogene rearrangement patterns on outcomes in patients with double\u2010hit non\u2010Hodgkin lymphoma"],"prefix":"10.1002","volume":"122","author":[{"given":"Daniel J.","family":"Landsburg","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Petrich","sequence":"additional","affiliation":[{"name":"Robert H. Lurie Comprehensive Cancer Center Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy S.","family":"Abramson","sequence":"additional","affiliation":[{"name":"Center for Lymphoma Massachusetts General Hospital Cancer Center Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliyah R.","family":"Sohani","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Press","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Cassaday","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C.","family":"Chavez","sequence":"additional","affiliation":[{"name":"Department of Malignant Hematology H. Lee Moffitt Cancer Center Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Song","sequence":"additional","affiliation":[{"name":"Leukemia\/BMT Program of British Columbia British Columbia Cancer Agency Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Zelenetz","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitul","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Robert H. Lurie Comprehensive Cancer Center Northwestern University Chicago Illinois"},{"name":"Virginia Cancer Specialists Fairfax Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrata","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy S.","family":"Fenske","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Jaso","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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