{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T21:45:30Z","timestamp":1785793530943,"version":"3.56.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The age\u2010adjusted annual incidence of non\u2010Hodgkin lymphoma (NHL) has risen worldwide. This trend may be affected by the secular increase in height and the sharp upswing in adolescent overweight; these drive increased insulinlike growth factor 1 and chronic inflammation, which may play an etiologic role. This study examined the association of the body mass index (BMI) and height of adolescents with NHL subtypes, which have been insufficiently evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Health\u2010related data on 2,352,988 Israeli adolescents, aged 16 to 19 years, who were examined between 1967 and 2011 were linked to the Israel National Cancer Registry to derive the NHL incidence up to December 31, 2012 (4021 cases). Cox proportional hazards modeling was used to estimate the multivariate\u2010adjusted hazard ratio (HR) for NHL subtypes associated with the BMI and height of adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Adolescent overweight and obesity were associated with an HR of 1.25 (95% confidence interval [CI], 1.13\u20101.37; <jats:italic>P<\/jats:italic>\u2009=\u20091.14\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>) for NHL in comparison with normal weight. There was a graded association of height with NHL (<jats:italic>P<\/jats:italic>\u2009=\u20094.29\u2009\u00d7\u200910<jats:sup>\u22129<\/jats:sup>), with the tallest adolescents (\u226595th percentile vs 25th to\u2009&lt;\u200950th percentiles [US Centers for Disease Control and Prevention]) exhibiting an HR of 1.28 (95% CI, 1.04\u20101.56). Marginal zone lymphoma, primary cutaneous lymphoma (PCL), and diffuse large B\u2010cell lymphoma (DLBCL) showed the strongest associations for overweight\/obesity, and DLBCL and PCL showed the strongest associations for height.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The findings of this large cohort study add to the growing body of evidence showing that higher body weight and taller stature during adolescence are associated with an increased risk of NHL and may modestly contribute to its increasing incidence. Further studies are needed to elucidate the mechanisms linking anthropometric measures and NHL risk. <jats:bold><jats:italic>Cancer<\/jats:italic> 2016;122:1068\u20131077.<\/jats:bold> \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.29792","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T10:31:10Z","timestamp":1456137070000},"page":"1068-1077","source":"Crossref","is-referenced-by-count":35,"title":["Adolescent weight and height are predictors of specific non\u2010Hodgkin lymphoma subtypes among a cohort of 2,352,988 individuals aged 16 to 19 years"],"prefix":"10.1002","volume":"122","author":[{"given":"Merav","family":"Leiba","sequence":"first","affiliation":[{"name":"Division of Hematology and Bone Marrow Transplantation Sheba Medical Center Ramat Gan Israel"},{"name":"Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Leiba","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Surgeon General Headquarters Medical Corps, Israel Defense Forces Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lital","family":"Keinan\u2010Boker","sequence":"additional","affiliation":[{"name":"Israel National Cancer Registry Israel Center for Disease Control, Ministry of Health Ramat Gan Israel"},{"name":"School of Public Health University of Haifa Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Avigdor","sequence":"additional","affiliation":[{"name":"Division of Hematology and Bone Marrow Transplantation Sheba Medical Center Ramat Gan Israel"},{"name":"Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Derazne","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Surgeon General Headquarters Medical Corps, Israel Defense Forces Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagai","family":"Levine","sequence":"additional","affiliation":[{"name":"Hebrew University\u2013Hadassah School of Public Health and Community Medicine Jerusalem Israel"},{"name":"Department of Preventive Medicine Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D.","family":"Kark","sequence":"additional","affiliation":[{"name":"Hebrew University\u2013Hadassah School of Public Health and Community Medicine Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-051672"},{"key":"e_1_2_7_3_1","unstructured":"International Agency for Research on Cancer.GLOBOCAN 2012: estimated cancer incidence mortality and prevalence worldwide in 2012.http:\/\/globocan.iarc.fr\/Default.aspx. 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