{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:49:45Z","timestamp":1791308985096,"version":"4.3.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T00:00:00Z","timestamp":1447977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,2,15]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>An accurate staging system is crucial for cancer management. Evaluations for continual suitability and improvement are needed as staging and treatment methods evolve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This was a retrospective study of 1609 patients with nasopharyngeal carcinoma investigated by magnetic resonance imaging, staged with the 7th edition of the American Joint Committee on Cancer (AJCC)\/International Union Against Cancer (UICC) staging system, and irradiated by intensity\u2010modulated radiotherapy at 2 centers in Hong Kong and mainland China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among the patients without other T3\/T4 involvement, there were no significant differences in overall survival (OS) between medial pterygoid muscle (MP)\u2009\u00b1\u2009lateral pterygoid muscle (LP), prevertebral muscle, and parapharyngeal space involvement. Patients with extensive soft tissue involvement beyond the aforementioned structures had poor OS similar to that of patients with intracranial extension and\/or cranial nerve palsy. Only 2% of the patients had lymph nodes\u2009&gt;\u20096\u2009cm above the supraclavicular fossa (SCF), and their outcomes resembled the outcomes of those with low extension. Replacing SCF with the lower neck (extension below the caudal border of the cricoid cartilage) did not affect the hazard distinction between different N categories. With the proposed T and N categories, there were no significant differences in outcome between T4N0\u20102 and T1\u20104N3 disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      After a review by AJCC\/UICC preparatory committees, the changes recommended for the 8th edition include changing MP\/LP involvement from T4 to T2, adding prevertebral muscle involvement as T2, replacing SCF with the lower neck and merging this with a maximum nodal diameter\u2009&gt;\u20096\u2009cm as N3, and merging T4 and N3 as stage IVA criteria. These changes will lead not only to a better distinction of hazards between adjacent stages\/categories but also to optimal balance in clinical practicability and global applicability.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2016;122:546\u2013558.\n                      <\/jats:bold>\n                      \u00a9\n                      <jats:italic>2015 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.29795","type":"journal-article","created":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T11:12:57Z","timestamp":1448017977000},"page":"546-558","source":"Crossref","is-referenced-by-count":316,"title":["Proposal for the 8th edition of the\n                    <scp>AJCC<\/scp>\n                    \/\n                    <scp>UICC<\/scp>\n                    staging system for nasopharyngeal cancer in the era of intensity\u2010modulated radiotherapy"],"prefix":"10.1002","volume":"122","author":[{"given":"Jian Ji","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Fujian Provincial Cancer Hospital Provincial Clinical College of Fujian Medical University Fuzhou China"},{"name":"Fujian Provincial Key Laboratory of Translational Cancer Medicine Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Tong","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Feng","family":"Zong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Fujian Provincial Cancer Hospital Provincial Clinical College of Fujian Medical University Fuzhou China"},{"name":"Fujian Provincial Key Laboratory of Translational Cancer Medicine Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy L. 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