{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:38:16Z","timestamp":1791545896142,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T00:00:00Z","timestamp":1449619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>During hospitalization for hematopoietic stem cell transplantation (HCT), patients experience a steep deterioration in quality of life (QOL) and mood. To our knowledge, the impact of this deterioration on patients' QOL and posttraumatic stress disorder (PTSD) symptoms after HCT is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We conducted a prospective longitudinal study of patients hospitalized for HCT. They assessed QOL using the Functional Assessment of Cancer Therapy\u2010Bone Marrow Transplantation (FACT\u2010BMT) and depression and anxiety symptoms were assessed using the Patient Health Questionnaire\u20109 (PHQ\u20109) at the time of admission for HCT, during hospitalization, and 6 months after HCT. We also used the Hospital Anxiety and Depression Scale (HADS) to measure patients' anxiety and depression symptoms at baseline and during HCT hospitalization. The PTSD Checklist was used to assess for PTSD symptoms. Multivariable linear regression models were used to identify predictors of QOL and PTSD symptoms at 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We enrolled 90 of 93 consecutively eligible patients (97%) undergoing autologous and allogeneic HCT. Data at 6 months were available for 67 participants. At 6 months, 28.4% of participants met the criteria for PTSD and 43.3% had clinically significant depression. On multivariable regression analyses adjusting for significant covariates, changes in QOL and depression scores from week 2 of HCT hospitalization to baseline predicted worse QOL (changes in scores between week 2 and baseline [\u0394] QOL: \u03b2, 0.94 [\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.0001] and \u0394 PHQ\u20109: \u03b2, \u22122.59 [\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001]) and PTSD symptoms (\u0394 QOL: \u03b2, \u22120.40 [\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.0001] and \u0394 PHQ\u20109: \u03b2, 1.26 [\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.0001]) at 6 months after HCT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Six months after HCT, a significant percentage of patients met the criteria for PTSD and depression. A decline in QOL and an increase in depressive symptoms during hospitalization for HCT were found to be the most important predictors of 6\u2010month QOL impairment and PTSD symptoms. Therefore, managing symptoms of depression and QOL deterioration during HCT hospitalization may be critical to improving QOL at 6 months and reducing the risk of PTSD.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2016;122:806\u2013812.\n                      <\/jats:bold>\n                      \u00a9\n                      <jats:italic>2015 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.29818","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T14:59:20Z","timestamp":1449759560000},"page":"806-812","source":"Crossref","is-referenced-by-count":121,"title":["Quality of life and mood predict posttraumatic stress disorder after hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"122","author":[{"given":"Areej R.","family":"El\u2010Jawahri","sequence":"first","affiliation":[{"name":"Bone Marrow Transplant Program Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry B.","family":"Vandusen","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Program Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara N.","family":"Traeger","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel N.","family":"Fishbein","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Program Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Keenan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily R.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Program Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Greer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Pirl","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki A.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Palliative Care Department Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Spitzer","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Program Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Bin A.","family":"Chen","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Program Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Temel","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.06.077"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.130"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1399"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-182592"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.19.2335"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2430"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2013.228"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704788"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704709"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.12.519"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.70.1.235"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29149"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700672"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024719104351"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-2004"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704646"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2011.08.011"},{"key":"e_1_2_7_21_1","unstructured":"National 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