{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:55:18Z","timestamp":1785009318443,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:00:00Z","timestamp":1452816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institutes of Health to the Children's Oncology Group","award":["CA13539"],"award-info":[{"award-number":["CA13539"]}]},{"name":"National Institutes of Health to the Children's Oncology Group","award":["CA98543"],"award-info":[{"award-number":["CA98543"]}]},{"name":"Division of Cancer Prevention of the National Cancer Institute to the Children's Oncology Group"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>This prospective study describes the procedure\u2010related anxiety, treatment\u2010related anxiety, pain, and nausea experienced by children with standard\u2010risk acute lymphoblastic leukemia (ALL) during the first year of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This study was undertaken at 31 Children's Oncology Group (COG) sites. Eligible children who were 2 to 9.99 years old were enrolled in a COG trial for patients with newly diagnosed standard\u2010risk ALL from 2005 to 2009. Parents completed a demographic survey at the baseline and the Pediatric Quality of Life Inventory 3.0 Cancer Module (proxy version) and the General Functioning Scale of the Family Assessment Device 1, 6, and 12 months after the diagnosis. The association between patient\u2010related (age, sex, ethnicity, and treatment), parent\u2010related (marital status and education), and family\u2010related factors (functioning, income, and size) and symptom scores was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The mean scores for procedure\u2010related anxiety, treatment\u2010related anxiety, and pain improved during the first year of treatment (<jats:italic>P<\/jats:italic> &lt; .0389). The mean nausea score was poorer 6 months after the diagnosis in comparison with the other assessments (<jats:italic>P<\/jats:italic> = .0085). A younger age at diagnosis was associated with significantly worse procedure\u2010related anxiety (<jats:italic>P<\/jats:italic> = .004). An older age (<jats:italic>P<\/jats:italic> = .0002) and assignment to the intensified consolidation study arm (<jats:italic>P<\/jats:italic> = .02) were associated with significantly worse nausea.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Children with ALL experienced decreasing treatment\u2010related anxiety, procedure\u2010related anxiety, and pain during the first year of treatment. In comparison with scores at 1 and 12 months, nausea was worse 6 months after the diagnosis. Minimization of procedure\u2010related anxiety in younger children and improved nausea control in older children and those receiving more intensified treatment should be prioritized. <jats:bold><jats:italic>Cancer<\/jats:italic> 2016;122:1116\u20131125.<\/jats:bold> \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.29876","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T17:01:32Z","timestamp":1452963692000},"page":"1116-1125","source":"Crossref","is-referenced-by-count":97,"title":["Anxiety, pain, and nausea during the treatment of standard\u2010risk childhood acute lymphoblastic leukemia: A prospective, longitudinal study from the <scp>C<\/scp>hildren's <scp>O<\/scp>ncology <scp>G<\/scp>roup"],"prefix":"10.1002","volume":"122","author":[{"given":"L. Lee","family":"Dupuis","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Research Institute Hospital for Sick Children Toronto Canada"},{"name":"Leslie Dan Faculty of Pharmacy University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Public Health and Health Professions, College of Medicine University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah\u2010Rose","family":"Mitchell","sequence":"additional","affiliation":[{"name":"School of Medicine Yale University School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology Hospital for Sick Children Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Devidas","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Public Health and Health Professions, College of Medicine University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Leonard A.","family":"Mattano","sequence":"additional","affiliation":[{"name":"HARP Pharma Consulting Mystic Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Perlmutter Cancer Center, Langone Medical Center New York University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Winick","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\u2010Oncology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Hunger","sequence":"additional","affiliation":[{"name":"Division of Oncology and Center for Childhood Cancer Research Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly W.","family":"Maloney","sequence":"additional","affiliation":[{"name":"Center for Cancer and Blood Disorders Children's Hospital Colorado Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina S.","family":"Kadan\u2010Lottick","sequence":"additional","affiliation":[{"name":"Section of Pediatric Hematology\/Oncology Yale University School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.8018"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2014.09.017"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-009-0651-1"},{"key":"e_1_2_7_5_1","first-page":"59","article-title":"Quality of life and symptom prevalence in children with cancer in Lebanon: the perspective of parents","volume":"2","author":"Huijer H","year":"2013","journal-title":"Ann Palliat Med."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25433"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-200401000-00001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1574-9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2004.03.006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1182\/blood.V122.21.837.837","article-title":"Excellent event free (EFS) and overall survival (OS) for children with standard risk acute lymphoblastic leukemia (SR ALL) despite the absence of a significant impact on outcome with the addition of an intensified consolidation: results of Children's Oncology Group (COG) AALL0331 [abstract]","volume":"122","author":"Maloney K","year":"2013","journal-title":"Blood."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28578"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29708"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.1.18"},{"key":"e_1_2_7_14_1","unstructured":"ClinicalTrials.gov.Combination chemotherapy in treating young patients with newly diagnosed acute lymphoblastic leukemia.https:\/\/clinicaltrials.gov\/show\/NCT00103285. 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