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Although still considered aggressive and most often lethal, these brain tumors are associated with a more insidious clinical course and more favorable prognosis compared to the highly aggressive form in children. Treatment options for patients with brainstem gliomas still are limited and insufficiently studied. A better understanding of the pathobiology of these tumors will be crucial for the development of more specific and effective therapies. <jats:bold><jats:italic>Cancer<\/jats:italic> 2016<\/jats:bold>. \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic>. <jats:italic><jats:bold>Cancer 2016;122:2799\u20132809.<\/jats:bold> \u00a9 2016 American Cancer Society<\/jats:italic><\/jats:p>","DOI":"10.1002\/cncr.29920","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T21:07:14Z","timestamp":1466629634000},"page":"2799-2809","source":"Crossref","is-referenced-by-count":53,"title":["Adult brainstem gliomas"],"prefix":"10.1002","volume":"122","author":[{"given":"Sylvia C.","family":"Eisele","sequence":"first","affiliation":[{"name":"Center for Neuro\u2010Oncology Dana\u2010Farber\/Brigham and Women's Cancer Center Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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