{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:06:06Z","timestamp":1777935966067,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T00:00:00Z","timestamp":1478736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA21661"],"award-info":[{"award-number":["U10CA21661"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA180868"],"award-info":[{"award-number":["U10CA180868"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA180822"],"award-info":[{"award-number":["U10CA180822"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA37422"],"award-info":[{"award-number":["U10CA37422"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004897","name":"Pennsylvania Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Brief tools are needed to screen oncology outpatients for depressive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Patients starting radiotherapy for the first diagnosis of any tumor completed distress screening tools, including the 9\u2010item Patient Health Questionnaire (PHQ\u20109), the 2\u2010item Patient Health Questionnaire (PHQ\u20102), the National Comprehensive Cancer Network Distress Thermometer (NCCN\u2010DT), and the Hopkins Symptom Checklist (HSCL) (25\u2010item version). Patients exceeding validated cutoff scores and a systematic sample of patients whose screening was negative completed the Structured Clinical Interview for <jats:italic>DSM\u2010IV<\/jats:italic> (SCID) mood disorder modules via telephone.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Four hundred sixty\u2010three patients from 35 community\u2010based radiation oncology sites and 2 academic radiation oncology sites were recruited. Sixty\u2010six percent of the 455 eligible patients (n\u2009=\u2009299) were women, and the eligible patients had breast (45%), gastrointestinal (11%), lung (10%), gynecologic (6%), or other cancers (27%). Seventy\u2010five (16.5%) exceeded screening cutoffs for depressive symptoms. Forty\u2010two of these patients completed the SCID. Another 37 patients whose screening was negative completed the SCID. Among the 79 patients completing the SCID, 8 (10.1%) met the criteria for major depression, 2 (2.5%) met the criteria for dysthymia, and 6 (7.6%) met the criteria for an adjustment disorder. The PHQ\u20102 demonstrated good psychometric properties for screening for mood disorders with a cutoff score of \u22653 (receiver operating characteristic area under the curve [AUC], 0.83) and was comparable to the PHQ\u20109 (\u2009&gt;\u20099; AUC\u2009=\u20090.85). The NCCN\u2010DT did not detect depression (AUC\u2009=\u20090.59).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The PHQ\u20102 demonstrated good psychometric properties for screening for mood disorders, which were equivalent to the PHQ\u20109 and superior to the NCCN\u2010DT. These findings support using the PHQ\u20102 to identify patients in need of further assessment for depression, which has a low prevalence but is a clinically significant comorbidity. These findings could inform the implementation of distress screening accreditation standards. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:485\u2013493.<\/jats:bold> \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.29969","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T09:57:03Z","timestamp":1479290223000},"page":"485-493","source":"Crossref","is-referenced-by-count":32,"title":["Screening for depression in cancer patients receiving radiotherapy: Feasibility and identification of effective tools in the NRG Oncology RTOG 0841 trial"],"prefix":"10.1002","volume":"123","author":[{"given":"Lynne I.","family":"Wagner","sequence":"first","affiliation":[{"name":"Department of Social Sciences and Health Policy, Division of Public Health Sciences Wake Forest School of Medicine Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie 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