{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:18Z","timestamp":1786977498493,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,6,15]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>To evaluate tumor responses, event\u2010free survival (EFS), overall survival (OS), and toxicity of chemotherapy, children with neurofibromatosis type 1 (NF1) and progressive low\u2010grade glioma were enrolled into the Children's Oncology Group (COG) A9952 protocol and treated with carboplatin and vincristine (CV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Non\u2010NF1 patients were randomized to CV or thioguanine, procarbazine, 1\u2010(2\u2010chloroethyl)\u20103\u2010cyclohexyl\u20101\u2010nitrosourea, and vincristine in COG A9952. NF1 patients were assigned to CV only. NF1 patients and non\u2010NF1 patients who were treated with CV were compared with respect to baseline characteristics, toxicity, tumor responses, EFS, and OS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A total of 127 eligible patients with NF1 were nonrandomly assigned to CV: 42 NF1 patients (33%) had events, and 6 (4.7%) died. The 5\u2010year EFS rate was 69%\u2009\u00b1\u20094% for the CV\u2010NF1 group and 39%\u2009\u00b1\u20094% for the CV\u2013non\u2010NF1 group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). In a univariate analysis, NF1 children had a significantly higher tumor response rate and superior EFS and OS in comparison with CV\u2010treated children without NF1. NF1 patients and non\u2010NF1 patients differed significantly in amount of residual tumor, extent of resection, tumor location, and pathology. According to a multivariate analysis, NF1 was independently associated with better EFS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) but not with OS. NF1 patients also had a decreased risk of grade 3 or 4 toxicities in comparison with non\u2010NF1 patients. Three second malignant neoplasms occurred in NF1 patients receiving CV (CV\u2010NF1 group) at a median of 7.8 years (range, 7.3\u20109.4 years) after enrollment, but there were none in the non\u2010NF1 group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Children with NF1 tolerated CV well and had tumor response rates and EFS that were superior to those for children without NF1.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2016;122:1928\u201336\n                      <\/jats:bold>\n                      . \u00a9\n                      <jats:italic>2016 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.29987","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T14:24:20Z","timestamp":1460298260000},"page":"1928-1936","source":"Crossref","is-referenced-by-count":113,"title":["Nonrandomized comparison of neurofibromatosis type 1 and non\u2013neurofibromatosis type 1 children who received carboplatin and vincristine for progressive low\u2010grade glioma: A report from the Children's Oncology Group"],"prefix":"10.1002","volume":"122","author":[{"given":"Joann L.","family":"Ater","sequence":"first","affiliation":[{"name":"Division of Pediatrics The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire M.","family":"Mazewski","sequence":"additional","affiliation":[{"name":"Children's Health Care Atlanta Hematology\u2010Oncology, Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy N.","family":"Booth","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Freyer","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles, Children's Center for Cancer and Blood Diseases Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J.","family":"Packer","sequence":"additional","affiliation":[{"name":"Division of Pediatrics The University of Texas MD Anderson Cancer Center Houston 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