{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:09:04Z","timestamp":1789150144538,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T00:00:00Z","timestamp":1463011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,7,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Infertility, poor semen quality, and gonadal dysfunction are well recognized long\u2010term sequelae in male survivors of childhood acute lymphoblastic leukemia (ALL). However, few studies have investigated adult sexual functioning in these survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors studied 52 male survivors of childhood ALL at a median age of 28.5 years (range, 25\u201038 years)\u2009\u2265\u200910 years after diagnosis. In addition, 56 men without a history of cancer were recruited for an age\u2010matched control group. The participants completed the Derogatis Interview for Sexual Functioning self\u2010report. To analyze predictive factors for sexual dysfunction, variables assessing sociodemographic background, antileukemia treatment, testicular size, laboratory variables from current serum and semen samples, self\u2010reported depressive symptoms, and self\u2010reported physical functioning were included in multiple regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>ALL survivors had significantly poorer sexual functioning, as measured by the Derogatis Interview for Sexual Functioning self\u2010report, compared with the control group. Survivors had a similar frequency of sexual fantasies, autoerotic acts, and full erection during these activities as the control group, but they had less frequent sexual activity with a sexual partner, poorer self\u2010rated orgasms, and lower satisfaction with their sex life. Predictive factors for poorer sexual functioning were depressive symptoms, the absence of a relationship, and, to a lesser extent, testicular size as an indication of gonadal damage from childhood antileukemia therapy. Older survivors experienced a deeper decline in sexual functioning compared with men in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Decline in sexual functioning at an early adult age can be regarded as 1 of the late effects of childhood cancer. Monitoring these survivors' sexual health is indicated. <jats:bold><jats:italic>Cancer<\/jats:italic> 2016;122:2268\u201376<\/jats:bold>. \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.29989","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T10:13:47Z","timestamp":1463048027000},"page":"2268-2276","source":"Crossref","is-referenced-by-count":36,"title":["Sexual function in male long\u2010term survivors of childhood acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"122","author":[{"given":"Anu","family":"Haavisto","sequence":"first","affiliation":[{"name":"Institute of Behavioural Sciences University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Henriksson","sequence":"additional","affiliation":[{"name":"National Supervisory Authority for Welfare and Health, and Centre for Military Medicine, Finnish Defence Forces Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risto","family":"Heikkinen","sequence":"additional","affiliation":[{"name":"Department of Adolescent Psychiatry Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena\u2010Riitta","family":"Puukko\u2010Viertomies","sequence":"additional","affiliation":[{"name":"Department of Adolescent Psychiatry Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsi","family":"Jahnukainen","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology and Stem Cell Transplantation, Children\u00b4s Hospital University of Helsinki and Helsinki University Central Hospital Helsinki Finland"},{"name":"Department of Women's and Children's Health Karolinska Institute and University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.9037"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.07.1147"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12651"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21780"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.7933"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900386"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12193"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1641"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.09.040"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.1458"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-117150"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1274"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0702"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-013-0285-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00926239708403933"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-7358(88)90050-5"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hec.4730020305"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181ff0e2e"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03819.x"},{"key":"e_1_2_8_21_1","unstructured":"AaltoA AroAR TeperiJ.RAND\u201036 as a Measure of Health\u2010Related Quality of Life. 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