{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:13:27Z","timestamp":1779142407563,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T00:00:00Z","timestamp":1467072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,10,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Whether biochemical recurrence (BR) is a significant predictive factor of mortality after definitive radiation therapy for prostate cancer remains unknown. The aim of the current study was to investigate the relation between BR and overall mortality (OAM) in high\u2010risk prostate cancer patients who were treated with carbon\u2010ion radiotherapy (CIRT) and had long\u2010term follow\u2010up in 2 prospective trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>In the 2 phase 2 clinical trials, which involved 466 prostate cancer patients who received 63.0 to 66.0 Gy of CIRT (relative biological effect) in 20 fractions between 2000 and 2007, 324 patients who were deemed to be at high risk on the basis of the modified D'Amico classification criteria and received CIRT along with androgen\u2010deprivation therapy (ADT) were examined. The OAM rate was adjusted for the ADT duration, and multivariate analyses using a Cox proportional hazards model were performed for OAM with BR as a time\u2010dependent covariate.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The median follow\u2010up period was 107.4 months, and the 5\u2010 and 10\u2010year OAM rates after adjustments for the ADT duration were 7.0% (95% confidence interval [CI], 4.0%\u20109.4%) and 23.9% (95% CI, 16.4%\u201026.2%), respectively. A multivariate analysis revealed that the presence of BR (hazard ratio, 2.82; 95% Cl, 1.57\u20105.08; <jats:italic>P<\/jats:italic> = .001) was one of the predictive factors for OAM. On the other hand, the duration of ADT had no impact on OAM.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>BR after CIRT combined with ADT is an independent predictive factor for OAM in high\u2010risk prostate cancer patients. The results of this study could be applied to other high\u2010dose radiation therapies. <jats:bold><jats:italic>Cancer<\/jats:italic> 2016;122:3225\u201331<\/jats:bold>. \u00a9 2016 The Authors. <jats:italic>Cancer<\/jats:italic> published by Wiley Periodicals, Inc. on behalf of <jats:italic>American Cancer Society<\/jats:italic>. This is an open access article under the terms of the Creative Commons Attribution\u2010NonCommercial\u2010NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non\u2010commercial and no modifications or adaptations are made.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30050","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T06:17:24Z","timestamp":1467181044000},"page":"3225-3231","source":"Crossref","is-referenced-by-count":18,"title":["Significant impact of biochemical recurrence on overall mortality in patients with high\u2010risk prostate cancer after carbon\u2010ion radiotherapy combined with androgen deprivation therapy"],"prefix":"10.1002","volume":"122","author":[{"given":"Goro","family":"Kasuya","sequence":"first","affiliation":[{"name":"Research Center Hospital for Charged Particle Therapy National Institute of Radiological Sciences Chiba 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