{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:20:33Z","timestamp":1789784433351,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P30 CA33572"],"award-info":[{"award-number":["P30 CA33572"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["K05 CA136967"],"award-info":[{"award-number":["K05 CA136967"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Carr-Baird Family Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The authors sought to determine the effect of chemotherapy on the development of metabolic syndrome (MetS) in premenopausal and postmenopausal women undergoing (neo)adjuvant therapy for early\u2010stage breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 86 women with early\u2010stage (AJCC stage I\u2010III) breast cancer who were free from clinically diagnosed MetS (defined as 3 of 5 components of MetS) were prospectively tested for the presence of the 5 components of MetS within 1 week before initiating and after completing (neo)adjuvant chemotherapy. The 5 components of MetS measured were waist circumference; blood pressure; and fasting levels of blood glucose, triglycerides, and high\u2010density lipoprotein cholesterol. Anthropometrics (body weight, percentage body fat, fat mass), lipid profile (total cholesterol, low\u2010density lipoprotein cholesterol), glucose metabolism (insulin, homeostatic model assessment of insulin resistance, glycated hemoglobin), and inflammation (C\u2010reactive protein) also were examined before initiating and after completing treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The current study included 46 premenopausal and 40 postmenopausal women. All individual MetS components and the overall MetS score were found to be statistically significantly increased (<jats:italic>P<\/jats:italic>&lt;.01) after chemotherapy. Body weight, percentage body fat, fat mass, lipids, glucose metabolism, and inflammation also were found to be statistically significantly increased (<jats:italic>P<\/jats:italic>&lt;.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>A 12\u2010week to 18\u2010week course of chemotherapy appears to statistically significantly increase MetS and related anthropometrics, biomarkers of glucose metabolism, and inflammation in patients with early\u2010stage breast cancer with no preexisting MetS. Lifestyle interventions such as diet and exercise may be preventive approaches for use during chemotherapy to reduce the onset of MetS in patients with breast cancer. <jats:bold><jats:italic>Cancer<\/jats:italic> 2016<\/jats:bold>. \u00a9 <jats:italic>2016<\/jats:italic> The Authors. <jats:italic>Cancer<\/jats:italic> published by Wiley Periodicals, Inc. on behalf of <jats:italic>American Cancer Society<\/jats:italic>. <jats:italic><jats:bold>Cancer 2016;122:2646\u20132653.<\/jats:bold> \u00a9 2016 American Cancer Society.<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30104","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T23:19:22Z","timestamp":1464131962000},"page":"2646-2653","source":"Crossref","is-referenced-by-count":100,"title":["An observational study to examine changes in metabolic syndrome components in patients with breast cancer receiving neoadjuvant or adjuvant chemotherapy"],"prefix":"10.1002","volume":"122","author":[{"given":"Christina M.","family":"Dieli\u2010Conwright","sequence":"first","affiliation":[{"name":"Division of Biokinesiology and Physical Therapy University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Experimental Therapeutics City of Hope Comprehensive Cancer Center Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Waliany","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Experimental Therapeutics City of Hope Comprehensive Cancer Center Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Beckman Research Institute Division of Cancer Etiology City of Hope Comprehensive Cancer Center Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behrouz","family":"Salehian","sequence":"additional","affiliation":[{"name":"Department of Clinical Diabetes Endocrinology and Metabolism City of Hope Comprehensive Cancer Center Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne E.","family":"Mortimer","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Experimental Therapeutics City of Hope Comprehensive Cancer Center Duarte 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