{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:17:09Z","timestamp":1792289829098,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T00:00:00Z","timestamp":1466121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,9,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The surgical management of mammary intraductal papilloma without atypia (IDP) identified at core\u2010needle biopsy (CNB) is controversial. This study assessed the rate of upgrade to carcinoma at surgical excision (EXC).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This study identified women with a CNB diagnosis of intraductal papilloma without atypia or carcinoma at a cancer center between 2003 and 2013. Radiologic\u2010pathologic concordance was assessed for all cases, and discordant cases were excluded. The radiologic and clinicopathologic features of patients with a CNB diagnosis of IDP were correlated with an upgrade to carcinoma at EXC.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The study population consists of 189 women with 196 IDPs; 166 women (171 IDPs) underwent EXC. The upgrade rate was 2.3% (4 of 171). The upgraded lesions were 2 invasive lobular carcinomas and 2 cases of ductal carcinoma in situ (DCIS). One case of DCIS involved the residual IDP, whereas the other 3 carcinomas were\u2009\u2265\u20098\u2009mm away. Twenty\u2010four women (25 IDPs) did not undergo EXC and had stable imaging on follow\u2010up (median, 23.5 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The upgrade rate at EXC for IDPs diagnosed at CNB with radiologic\u2010pathologic concordance was 2.3%. These findings suggest that observation is appropriate for patients with radiologic\u2010pathologic concordant CNB yielding IDP, regardless of its size. <jats:bold><jats:italic>Cancer<\/jats:italic> 2016.<\/jats:bold> \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic>. <jats:italic><jats:bold>Cancer 2016;122:2819\u20132827.<\/jats:bold> \u00a9 2016 American Cancer Society<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30118","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T16:31:20Z","timestamp":1466181080000},"page":"2819-2827","source":"Crossref","is-referenced-by-count":83,"title":["Breast intraductal papillomas without atypia in radiologic\u2010pathologic concordant core\u2010needle biopsies: Rate of upgrade to carcinoma at excision"],"prefix":"10.1002","volume":"122","author":[{"given":"Fresia","family":"Pareja","sequence":"first","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana D.","family":"Corben","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra B.","family":"Brennan","sequence":"additional","affiliation":[{"name":"Department of Radiology Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa P.","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenica L.","family":"Bowser","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York New 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