{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T07:27:24Z","timestamp":1776065244693,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T00:00:00Z","timestamp":1466121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Public Health Service","award":["5U24-CA076518"],"award-info":[{"award-number":["5U24-CA076518"]}]},{"DOI":"10.13039\/100000054","name":"the National Cancer Institute (NCI)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"the National Heart, Lung, and Blood Institute (NHLBI)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"the National Institute of Allergy and Infectious Diseases (NIAID)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the NHLIB and the NCI","award":["5U10HL069294"],"award-info":[{"award-number":["5U10HL069294"]}]},{"name":"the Health Resources and Services Administration\/Department of Health and Human Services","award":["HHSH250201200016C"],"award-info":[{"award-number":["HHSH250201200016C"]}]},{"name":"the Health Resources and Services Administration\/Department of Health and Human Services","award":["N00014-13-1-0039"],"award-info":[{"award-number":["N00014-13-1-0039"]}]},{"name":"the Health Resources and Services Administration\/Department of Health and Human Services","award":["N00014-14-1-0028"],"award-info":[{"award-number":["N00014-14-1-0028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Patients with FMS like tyrosine kinase 3 (FLT3)\u2010mutated acute myeloid leukemia (AML) have a poor prognosis and are referred for early allogeneic hematopoietic stem cell transplantation (HCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Data from the Center for International Blood and Marrow Transplant Research (CIBMTR) were used to evaluate 511 adult patients with de novo AML who underwent HCT during 2008 through 2011 to determine whether FLT3 mutations had an impact on HCT outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In total, 158 patients (31%) had FLT3 mutations. Univariate and multivariate analyses revealed an increased risk of relapse at 3 years in the FLT3 mutated group compared with the wild\u2010type (WT) group (38% [95% confidence interval (CI), 30%\u201045%] vs 28% [95% CI, 24%\u201033%]; <jats:italic>P<\/jats:italic>\u2009=\u2009.04; relative risk, 1.60 [95% CI, 1.15\u20102.22]; <jats:italic>P<\/jats:italic>\u2009=\u2009.0048). However, FLT3 mutation status was not significantly associated with nonrelapse mortality, leukemia\u2010free survival, or overall survival. Although more patients in the FLT3 mutated group died from relapsed primary disease compared with those in the WT group (60% vs 46%), the 3\u2010year overall survival rate was comparable for the 2 groups (mutated group: 49%; 95% CI, 40%\u201057%; WT group: 55%, 95% CI, 50%\u201060%; <jats:italic>P<\/jats:italic>\u2009=\u2009.20).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The current data indicate that FLT3 mutation status did not adversely impact overall survival after HCT, and about 50% of patients with this mutation who underwent HCT were long\u2010term survivors. <jats:bold><jats:italic>Cancer<\/jats:italic> 2016;122:3005\u20103014<\/jats:bold>. \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30140","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T16:31:25Z","timestamp":1466181085000},"page":"3005-3014","source":"Crossref","is-referenced-by-count":46,"title":["Does FLT3 mutation impact survival after hematopoietic stem cell transplantation for acute myeloid leukemia? A Center for International Blood and Marrow Transplant Research (CIBMTR) analysis"],"prefix":"10.1002","volume":"122","author":[{"given":"Abhinav","family":"Deol","sequence":"first","affiliation":[{"name":"Department of Oncology, Karmanos Cancer Institute Wayne State University Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salyka","family":"Sengsayadeth","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang Woo","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for International Blood and Marrow Transplant Research Medical College of Wisconsin Milwaukee Wisconsin"},{"name":"Division of Biostatistics, Institute for Health and Society Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for International Blood and Marrow Transplant Research Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Aljurf","sequence":"additional","affiliation":[{"name":"Department of Oncology King Faisal Specialist Hospital Center and Research Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph Harry","family":"Antin","sequence":"additional","affiliation":[{"name":"Center for Hematologic Oncology, Department of Medical Oncology Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoo","family":"Battiwalla","sequence":"additional","affiliation":[{"name":"Hematology Branch, National Heart, Lung, and Blood Institute Bethesda 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