{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:49:28Z","timestamp":1793321368226,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T00:00:00Z","timestamp":1468281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>High\u2010dose, post\u2010transplantation cyclophosphamide (PTCy) to prevent graft\u2010versus\u2010host disease (GVHD) has improved outcomes in haploidentical (HAPLO) stem cell transplantation (SCT). However, it remains unclear whether this strategy is effective in SCT from 1\u2010antigen human leukocyte antigen (HLA)\u2010mismatched unrelated donors (9\/10 MUD) and how the outcomes of these patients compare with those of haploidentical transplantation recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A parallel, 2\u2010arm, nonrandomized phase 2 clinical trial was conducted of melphalan\u2010based reduced\u2010intensity conditioning with PTCy, tacrolimus, and mycophenolate mofetil to prevent GVHD in patients with high\u2010risk hematologic malignancies who underwent HAPLO (n = 60) or 9\/10 MUD (n = 46) SCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The 1\u2010year overall and progression\u2010free survival rates were 70% and 60%, respectively, in the HAPLO arm and 60% and 47%, respectively, in the 9\/10 MUD arm. The day +100 cumulative incidence of grade II to IV acute GVHD and grade III to IV acute GVHD was 28% and 3%, respectively, in the HAPLO arm and 33% and 13%, respectively, in the 9\/10 MUD arm. The 2\u2010year cumulative incidence of chronic GVHD was 24% in the HAPLO arm and 19% in the 9\/10 MUD arm. The 1\u2010year cumulative incidence of nonrelapse mortality was 21% in the HAPLO arm and 31% in the 9\/10 MUD arm, and the 1\u2010year relapse rate was 19% in the HAPLO arm and 25% in the 9\/10 MUD arm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Although this was a nonrandomized study and could not serve as a direct comparison between the 2 groups, the authors conclude that PTCy\u2010based GVHD prophylaxis is effective for both HAPLO and 9\/10 MUD SCTs. Prospective randomized trials will be required to compare the efficacies of alternative donor options for patients lacking HLA\u2010matched donors.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2016;122:3316\u20133326\n                      <\/jats:bold>\n                      . \u00a9\n                      <jats:italic>2016 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.30180","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T10:26:52Z","timestamp":1468319212000},"page":"3316-3326","source":"Crossref","is-referenced-by-count":84,"title":["Results of a 2\u2010arm, phase 2 clinical trial using post\u2010transplantation cyclophosphamide for the prevention of graft\u2010versus\u2010host disease in haploidentical donor and mismatched unrelated donor hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"122","author":[{"given":"Sameh","family":"Gaballa","sequence":"first","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabell","family":"Ge","sequence":"additional","affiliation":[{"name":"University Medical Center Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riad","family":"El Fakih","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan E.","family":"Brammer","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston 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