{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:15:07Z","timestamp":1782738907865,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T00:00:00Z","timestamp":1471305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Children of Hispanic ancestry have a higher incidence of acute lymphoblastic leukemia (ALL) compared with other ethnic groups, but to the authors' knowledge, the genetic basis for these racial disparities remain incompletely understood. Genome\u2010wide association studies of childhood ALL to date have focused on inherited genetic effects; however, maternal genetic effects (the role of the maternal genotype on phenotype development in the offspring) also may play a role in ALL susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors conducted a family\u2010based exome\u2010wide association study of maternal genetic effects among Hispanics with childhood B\u2010cell ALL using the Illumina Infinium HumanExome BeadChip. A discovery cohort of 312 Guatemalan and Hispanic American families and an independent replication cohort of 152 Hispanic American families were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Three maternal single\u2010nucleotide polymorphisms (SNPs) approached the study threshold for significance after correction for multiple testing (<jats:italic>P<\/jats:italic>&lt;1.0\u2009\u00d7\u200910<jats:sup>\u22126<\/jats:sup>): <jats:italic>MTL5<\/jats:italic> rs12365708 (testis expressed metallothionein\u2010like protein [tesmin]) (relative risk [RR], 2.62; 95% confidence interval [95% CI], 1.61\u20104.27 [<jats:italic>P\u2009=\u2009<\/jats:italic>1.8\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>]); <jats:italic>ALKBH1<\/jats:italic> rs6494 (AlkB homolog 1, histone H2A dioxygenase) (RR, 3.77; 95% CI, 1.84\u20107.74 [<jats:italic>P\u2009=\u2009<\/jats:italic>3.7\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>]); and <jats:italic>NEUROG3<\/jats:italic> rs4536103 (neurogenin 3) (RR, 1.75; 95% CI, 1.30\u20102.37 [<jats:italic>P\u2009=\u2009<\/jats:italic>1.2\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>]). Although effect sizes were similar, these SNPs were not nominally significant in the replication cohort in the current study. In a meta\u2010analysis comprised of the discovery cohort and the replication cohort, these SNPs were still not found to be statistically significant after correction for multiple comparisons (rs12365708: pooled RR, 2.27 [95% CI, 1.48\u20103.50], <jats:italic>P\u2009=\u2009<\/jats:italic>1.99\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>; rs6494: pooled RR, 2.31 [95% CI, 1.38\u20103.85], <jats:italic>P\u2009=\u2009<\/jats:italic>.001; and rs4536103: pooled RR, 1.67 [95% CI, 1.29\u20102.16] <jats:italic>P\u2009=\u2009<\/jats:italic>9.23\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In what to the authors' knowledge is the first family\u2010based based exome\u2010wide association study to investigate maternal genotype effects associated with childhood ALL, the results did not implicate a strong role of maternal genotype on disease risk among Hispanics; however, 3 maternal SNPs were identified that may play a modest role in susceptibility. <jats:bold><jats:italic>Cancer<\/jats:italic> 2016;122:3697\u2010704.<\/jats:bold> \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30241","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T12:23:23Z","timestamp":1471350203000},"page":"3697-3704","source":"Crossref","is-referenced-by-count":21,"title":["Family\u2010based exome\u2010wide assessment of maternal genetic effects on susceptibility to childhood B\u2010cell acute lymphoblastic leukemia in hispanics"],"prefix":"10.1002","volume":"122","author":[{"given":"Natalie P.","family":"Archer","sequence":"first","affiliation":[{"name":"Austin Regional Campus University of Texas School of Public Health Austin Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Perez\u2010Andreu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences St. Jude Children's Research Hospital Memphis Tennessee"},{"name":"Hematologic Malignancies Program Comprehensive Cancer Center, St. Jude Children's Research Hospital Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Scheurer","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology, Department of Pediatrics Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen R.","family":"Rabin","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology, Department of Pediatrics Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin C.","family":"Peckham\u2010Gregory","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology, Department of Pediatrics Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon E.","family":"Plon","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology, Department of Pediatrics Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan C.","family":"Zabriskie","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology, Department of Pediatrics Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A.","family":"De Alarcon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Illinois College of Medicine at Peoria Peoria Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen S.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Illinois College of Medicine at Peoria Peoria Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar 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