{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T21:04:26Z","timestamp":1774731866458,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T00:00:00Z","timestamp":1470787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Clinical and Translational Science Center at Weill Cornell Medical College","award":["UL1TR000457"],"award-info":[{"award-number":["UL1TR000457"]}]},{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"crossref","award":["T32 000,027"],"award-info":[{"award-number":["T32 000,027"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007052","name":"Memorial Sloan Kettering Cancer Center","doi-asserted-by":"crossref","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100007052","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2016,12,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Obesity is associated with increased adipose tissue in the tongue. Chronic white adipose tissue (WAT) inflammation commonly occurs in the obese. We investigated whether WAT inflammation in the tongue impacts survival in patients with squamous cell carcinoma (SCC) of the oral tongue.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>In a retrospective cohort study, patients with T1 and T2 SCC of the oral tongue who underwent curative\u2010intent resection were included. Tongue WAT inflammation was defined by the presence of dead or dying adipocytes surrounded by macrophages forming crown\u2010like structures. The primary and secondary endpoints were disease\u2010specific survival (DSS) and overall survival (OS), respectively. Subgroup analyses were carried out in patients without lymph node involvement for whom adjuvant therapies were not indicated.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Archived tissue was available from 125 patients. The median follow\u2010up was 55 months (range, 3\u2010156 months). Overall, 49 of 125 patients (39%) had tongue WAT inflammation, which was associated with higher body mass index, increased tumor thickness, and vascular invasion (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). The 3\u2010year DSS rate for patients with tongue WAT inflammation was 59% (95% confidence interval [CI], 46%\u201076%) versus 82% (95% CI, 73%\u201092%) for those without inflammation. For patients without lymph node involvement for whom adjuvant therapy was not indicated (N\u2009=\u200970), tongue WAT inflammation was associated with shortened DSS and OS (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). When adjusted for body mass index and potential prognostic covariates, the hazard ratio for DSS and OS was 5.40 (95% CI, 1.20\u201024.26) and 2.97 (95% CI, 1.02\u20108.65), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Tongue WAT inflammation is associated with worse DSS and OS in patients who have early stage SCC of the oral tongue. <jats:bold><jats:italic>Cancer<\/jats:italic> 2016;122:3794\u20133802.<\/jats:bold> \u00a9 <jats:italic>2016 American Cancer Society.<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30251","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T09:33:55Z","timestamp":1470821635000},"page":"3794-3802","source":"Crossref","is-referenced-by-count":46,"title":["White adipose tissue inflammation and cancer\u2010specific survival in patients with squamous cell carcinoma of the oral tongue"],"prefix":"10.1002","volume":"122","author":[{"given":"Neil 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