{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:13:09Z","timestamp":1790745189271,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T00:00:00Z","timestamp":1472169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Lymph node metastases are an important cause of treatment failure for pediatric and adolescent\/young adult (AYA) sarcoma patients. Nodal sampling is recommended for certain sarcoma subtypes that have a predilection for lymphatic spread. Sentinel lymph node biopsy (SLNB) may improve the diagnostic yield of nodal sampling, particularly when single\u2010photon emission computed tomography\/computed tomography (SPECT\u2010CT) is used to facilitate anatomic localization. Functional imaging with positron emission tomography\/computed tomography (PET\u2010CT) is increasingly used for sarcoma staging and is a less invasive alternative to SLNB. To assess the utility of these 2 staging methods, this study prospectively compared SLNB plus SPECT\u2010CT with PET\u2010CT for the identification of nodal metastases in pediatric and AYA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Twenty\u2010eight pediatric and AYA sarcoma patients underwent SLNB with SPECT\u2010CT. The histological findings of the excised lymph nodes were then correlated with preoperative PET\u2010CT imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A median of 2.4 sentinel nodes were sampled per patient. No wound infections or chronic lymphedema occurred. SLNB identified tumors in 7 of the 28 patients (25%), including 3 patients who had normal PET\u2010CT imaging of the nodal basin. In contrast, PET\u2010CT demonstrated hypermetabolic regional nodes in 14 patients, and this resulted in a positive predictive value of only 29%. The sensitivity and specificity of PET\u2010CT for detecting histologically confirmed nodal metastases were only 57% and 52%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>SLNB can safely guide the rational selection of nodes for biopsy in pediatric and AYA sarcoma patients and can identify therapy\u2010changing nodal disease not appreciated with PET\u2010CT. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;155\u2013160.<\/jats:bold> \u00a9 <jats:italic>2016 American Cancer Society.<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30282","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T09:44:19Z","timestamp":1472204659000},"page":"155-160","source":"Crossref","is-referenced-by-count":58,"title":["Detection of lymph node metastases in pediatric and adolescent\/young adult sarcoma: Sentinel lymph node biopsy versus fludeoxyglucose positron emission tomography imaging\u2014A prospective trial"],"prefix":"10.1002","volume":"123","author":[{"given":"Lars M.","family":"Wagner","sequence":"first","affiliation":[{"name":"Division of Pediatric Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Medical Center University of Cincinnati Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Kremer","sequence":"additional","affiliation":[{"name":"Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Medical Center University of Cincinnati Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Gelfand","sequence":"additional","affiliation":[{"name":"Division of Pediatric Radiology and Medical Imaging, Cincinnati Children's Medical Center University of Cincinnati Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Sharp","sequence":"additional","affiliation":[{"name":"Division of Pediatric Radiology and Medical Imaging, Cincinnati Children's Medical Center University of Cincinnati Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Turpin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Medical Center University of Cincinnati Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajaram","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Medical Center University of Cincinnati Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Tiao","sequence":"additional","affiliation":[{"name":"Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Medical Center University of Cincinnati Cincinnati 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