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This review explores previously investigated first\u2010line intravesical therapies and discusses emerging second\u2010line treatments for the heterogeneous group of patients for whom BCG has failed. The myriad of recently published and ongoing trials assessing novel salvage intravesical treatments offer promise to patients who both seek an effective cure and want to avoid radical surgery. However, these trials must carefully be contextualized by specific patient, tumor, and recurrence characteristics. As data continue to accumulate, there will potentially be a role for these agents as second\u2010line or even first\u2010line intravesical therapies. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:390\u2013400.<\/jats:bold> \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/cncr.30392","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T13:44:27Z","timestamp":1478094267000},"page":"390-400","source":"Crossref","is-referenced-by-count":45,"title":["Non\u2013muscle\u2010invasive bladder cancer: Intravesical treatments beyond Bacille <scp>C<\/scp>almette\u2010<scp>G<\/scp>u\u00e9rin"],"prefix":"10.1002","volume":"123","author":[{"given":"Vignesh T.","family":"Packiam","sequence":"first","affiliation":[{"name":"Section of Urology, Department of Surgery University of Chicago Medical Center Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott 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