{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:52:27Z","timestamp":1770972747214,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T00:00:00Z","timestamp":1479254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,3,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The purpose of this study was to determine the effect of retroperitoneal (RP) exploration on progression\u2010free survival (PFS) and overall survival (OS) in epithelial ovarian cancer (EOC) patients with stage IIIC disease who underwent optimal debulking surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Data were collected from records of the Gynecologic Oncology Group 182 (GOG\u2010182) study of stage IIIC EOC patients cytoreduced to no gross residual disease (R0) or minimal gross residual (&lt;1\u2009cm) disease (MGRD) at primary surgery. Patients with stage IIIC disease by intraperitoneal (IP) tumor were included and divided into 3 groups: 1)\u2009&gt;\u20092\u2009cm IP tumor without lymph node involvement (IP\/RP\u2212), 2)\u2009&gt;\u20092\u2009cm IP tumor with lymph node involvement (IP\/RP+), and 3)\u2009&gt;\u20092\u2009cm IP tumor with no RP exploration (IP\/RP?). The effects of disease distribution and RP exploration on PFS and OS were assessed using Kaplan\u2013Meier and proportional hazards methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>There were 1871 stage IIIC patients in GOG\u2010182 who underwent optimal primary debulking surgery. Of these, 689 (36.8%) underwent RP exploration with removal of lymph nodes from at least 1 para\u2010aortic site, and 1182 (63.2%) did not. There were 269 patients in the IP\/RP\u2212 group, 420 patients in the IP\/RP\u2009+\u2009group, and 1182 patients in the IP\/RP? group. Improved PFS (18.5 vs 16.0 months; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001) and OS (53.3 vs 42.8 months; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001) were associated with RP exploration versus no exploration. Patients with MGRD had improved PFS (16.8 vs 15.1 months, <jats:italic>P<\/jats:italic>\u2009=\u20090.0108) and OS (44.9 vs 40.5 months, <jats:italic>P<\/jats:italic>\u2009=\u20090.0076) versus no exploration.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>RP exploration at the time of primary surgery in patients with optimally debulked stage IIIC EOC is associated with a survival benefit. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:985\u201393.<\/jats:bold> \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30414","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T15:20:45Z","timestamp":1479309645000},"page":"985-993","source":"Crossref","is-referenced-by-count":12,"title":["What is the role of retroperitoneal exploration in optimally debulked stage IIIC epithelial ovarian cancer? An NRG Oncology\/Gynecologic Oncology Group ancillary data study"],"prefix":"10.1002","volume":"123","author":[{"given":"Bunja J.","family":"Rungruang","sequence":"first","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Medical College of Georgia of Augusta University Augusta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin","family":"Miller","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Group, Statistical and Data Center, Roswell Park Cancer Institute Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas C.","family":"Krivak","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Western Pennsylvania Allegheny Hospital Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil S.","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Brigham &amp; Women's Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Kaiser Permanente Irvine Medical Center Irvine California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad A.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Service, Department of Obstetrics and Gynecology, Walter Reed National Military Medical Center Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floor J.","family":"Backes","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department Obstetrics and Gynecology Ohio State University Medical Center Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda F.","family":"Carson","sequence":"additional","affiliation":[{"name":"Department of OB\/GYN and Women's Health University of Minnesota School of Medicine Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Friedlander","sequence":"additional","affiliation":[{"name":"Department of Cancer Medicine, ANZGOG, Peter MacCallum Cancer Centre East Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"Mutch","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Washington University School of Medicine St Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Goodheart","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology The University of Iowa Hospitals and Clinics Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnansu S.","family":"Tewari","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of California Medical Center\u2013Irvine Orange California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Wenham","sequence":"additional","affiliation":[{"name":"Department of Gynecology Oncology H. Lee Moffitt Cancer Center &amp; Research Institute Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Bookman","sequence":"additional","affiliation":[{"name":"Medical Oncology, Arizona Oncology Tuscon Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Larry","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Inova Fairfax Hospital Women's Center Falls Church Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott D.","family":"Richard","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Drexel University College of Medicine Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21208"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(74)90251-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(87)90260-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.1061"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(91)90099-Q"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(86)90092-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.12.015"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1993.1263"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70244-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.1998.09758.x"},{"key":"e_1_2_8_12_1","first-page":"413","article-title":"Primary cytoreductive surgery for epithelial ovarian cancer","volume":"61","author":"Hacker NF","year":"1983","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850501)55:9<2019::AID-CNCR2820550932>3.0.CO;2-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(92)90100-W"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1257"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1997.4633"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981015)83:8<1555::AID-CNCR10>3.0.CO;2-R"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5349"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.08.047"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.05.016"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2008.19.4.223"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.09.024"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2013.10.001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji102"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.1684"},{"key":"e_1_2_8_26_1","unstructured":"Gynecologic Oncology Group. Surgical Procedures Manual 2007.http:\/\/www.gog.org. Accessed August 30 2016."},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.06.017"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603803"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.3617"},{"key":"e_1_2_8_30_1","unstructured":"Lymphadenectomy in ovarian neoplasms (LION).https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00712218. Accessed August 30 2016."},{"key":"e_1_2_8_31_1","unstructured":"Pelvic and aortic\u2010cava lymphadenectomy randomized for ovarian cancer (CARACO).https:\/\/clinicaltrials.gov\/ct2\/show\/record\/NCT01218490. Accessed August 30 2016."},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.3106"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6232"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.30414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.30414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.30414","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.30414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T15:08:48Z","timestamp":1760281728000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.30414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,16]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,3,15]]}},"alternative-id":["10.1002\/cncr.30414"],"URL":"https:\/\/doi.org\/10.1002\/cncr.30414","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,16]]}}}