{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:19:05Z","timestamp":1789881545517,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA142783"],"award-info":[{"award-number":["R01 CA142783"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,3,15]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Mesothelium vascular cell adhesion molecule\u20101 (VCAM\u20101) expression in the metastatic epithelial ovarian cancer (EOC) microenvironment is induced by tumor and mediates tumor cell invasion. VCAM\u20101 imaging suggests expression during treatment is an indicator of platinum resistance. Here, we assess the potential prognostic significance of mesothelium VCAM\u20101 expression and prospectively evaluate whether soluble VCAM\u20101 (sVCAM\u20101) is a surrogate for mesothelium expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A retrospective review of EOC patients was performed to evaluate outcomes with mesothelium VCAM\u20101 expression determined by immunohistochemistry of peritoneum or omentum specimens. A prospective cohort of EOC patients was identified and followed through primary treatment. Serum for sVCAM\u20101 evaluation, which was performed via enzyme\u2010linked immunosorbent assay, was collected before surgery or neoadjuvant chemotherapy and at each treatment cycle. Peritoneal specimens were obtained during debulking to assess mesothelial VCAM\u20101 expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A retrospective review identified 54 advanced\u2010stage EOC patients. Patients expressing mesothelium VCAM\u20101 had shortened overall survival (44 vs 79 months,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.035) and progression\u2010free survival (18 vs 67 months,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.010); the median time to platinum resistance was 36 months for VCAM\u20101\u2013expressing patients and not yet determined for the VCAM\u20101\u2013negative group. In our prospective observational cohort, 18 EOC patients completed primary treatment; 3 were negative for mesothelium VCAM\u20101 expression, and sVCAM\u20101 did not vary between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Mesothelium VCAM\u20101 expression is negatively associated with progression\u2010free and overall survival in EOC. This is especially compelling in light of previous data suggesting that persistent VCAM\u20101 expression during treatment is an indicator of platinum resistance. Our pilot study had insufficient cases to determine whether sVCAM\u20101 would substitute for mesothelium expression.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2017;123:977\u201384.\n                      <\/jats:bold>\n                      \u00a9\n                      <jats:italic>2016 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.30415","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T11:57:25Z","timestamp":1478519845000},"page":"977-984","source":"Crossref","is-referenced-by-count":32,"title":["Mesothelium expression of vascular cell adhesion molecule\u20101 (VCAM\u20101) is associated with an unfavorable prognosis in epithelial ovarian cancer (EOC)"],"prefix":"10.1002","volume":"123","author":[{"given":"Jennifer M.","family":"Scalici","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Virginia Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Arapovic","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Virginia Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin J.","family":"Saks","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Virginia Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen A.","family":"Atkins","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Virginia Charlottesville Virginia"},{"name":"Cancer Center University of Virginia Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Petroni","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of Virginia Charlottesville Virginia"},{"name":"Cancer Center University of Virginia Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda R.","family":"Duska","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Virginia Charlottesville Virginia"},{"name":"Cancer Center University of Virginia Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill K.","family":"Slack\u2010Davis","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Cancer Biology University of Virginia Charlottesville Virginia"},{"name":"Cancer Center University of Virginia Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,7]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"National Cancer Institute.Surveillance Epidemiology and End Results Program. 2015.http:\/\/seer.cancer.gov\/statfacts\/html\/ovary.html. 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