{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:22:56Z","timestamp":1789010576880,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T00:00:00Z","timestamp":1480636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006399","name":"Spectrum Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Long\u2010term survival in patients with aggressive peripheral T\u2010cell lymphoma (PTCL) is generally poor, and there currently is no clear consensus regarding the initial therapy used for these diseases. Herein, the authors analyzed treatment patterns and outcomes in a prospectively collected cohort of patients with a new diagnosis of nodal PTCL in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Comprehensive Oncology Measures for Peripheral T\u2010cell Lymphoma Treatment (COMPLETE) is a prospective multicenter cohort study designed to identify the most common prevailing treatment patterns used for patients newly diagnosed with PTCL in the United States. Patients with nodal PTCL and completed records regarding baseline characteristics and initial therapy were included in this analysis. All statistical tests were 2\u2010sided.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Of a total of 499 patients enrolled, 256 (51.3%) had nodal PTCL and completed treatment records. As initial therapy, patients received doxorubicin\u2010containing regimens (41.8%), regimens containing doxorubicin plus etoposide (20.9%), other etoposide regimens (15.8%), other single\u2010agent or combination regimens (19.2%), and gemcitabine\u2010containing regimens (2.1%). Survival was found to be statistically significantly longer for patients who received doxorubicin (log\u2010rank\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.03). After controlling for disease histology and International Prognostic Index, results demonstrated a trend toward significance in mortality reduction in patients who received doxorubicin compared with those who did not (hazard ratio, 0.71; 95% confidence interval, 0.48\u20101.05 [\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.09]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      To the authors' knowledge, there is no clear standard of care in the treatment of patients with PTCL in the United States. Although efforts to improve frontline treatments are necessary, anthracyclines remain an important component of initial therapy for curative intent.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2017;123:1174\u20131183.\n                      <\/jats:bold>\n                      \u00a9\n                      <jats:italic>2016 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.30416","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T12:20:25Z","timestamp":1480681225000},"page":"1174-1183","source":"Crossref","is-referenced-by-count":79,"title":["A prospective cohort study of patients with peripheral T\u2010cell lymphoma in the United States"],"prefix":"10.1002","volume":"123","author":[{"given":"Kenneth R.","family":"Carson","sequence":"first","affiliation":[{"name":"Research Service, St Louis Veterans Affairs Medical Center St. Louis Missouri"},{"name":"Department of Medical Oncology, Division of Oncology Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Horwitz","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Memorial Sloan\u2010Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C.","family":"Pinter\u2010Brown","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California at Irvine Irvine California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven T.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Provost and Chief Scientific Officer Department of Hematology &amp; Hematopoietic Cell Transplantation City of Hope, Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Pro","sequence":"additional","affiliation":[{"name":"Department of Medicine Robert H. Lurie Comprehensive Cancer Center, Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Hsi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Federico","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Clinical and Public Health Medicine University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gisselbrecht","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology H\u00f4pital Saint Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schwartz","sequence":"additional","affiliation":[{"name":"MedNet Solutions Minnetonka Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Bellm","sequence":"additional","affiliation":[{"name":"MedNet Solutions Minnetonka Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Acosta","sequence":"additional","affiliation":[{"name":"Research and Development Spectrum Pharmaceuticals Inc Irvine California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei R.","family":"Shustov","sequence":"additional","affiliation":[{"name":"Department of Medicine Fred Hutchinson Cancer Research Center Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjana H.","family":"Advani","sequence":"additional","affiliation":[{"name":"Department of Medicine Stanford University Medical Center Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana A.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department 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California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Craig","sequence":"additional","affiliation":[{"name":"Department of Medicine West Virginia University Morgantown West Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Greer","sequence":"additional","affiliation":[{"name":"Department of Hematology Vanderbilt University Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad S.","family":"Kahl","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Division of Oncology Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph W.","family":"Leach","sequence":"additional","affiliation":[{"name":"Minnesota Oncology Virginia Piper Cancer Institute Minneapolis 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