{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:36:22Z","timestamp":1761129382742,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T00:00:00Z","timestamp":1478563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K07CA172298","K05CA152715"],"award-info":[{"award-number":["K07CA172298","K05CA152715"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,3,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Although previous studies have noted an increased risk of colorectal cancer (CRC) among moderate to heavy alcohol consumers in comparison with nondrinkers, the relation between alcohol consumption and CRC survival remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Cases of incident invasive CRC diagnosed between 1997 and 2007 were identified via population\u2010based cancer registries at 4 study sites in the Colon Cancer Family Registry. Study participants completed a risk\u2010factor questionnaire on prediagnostic behaviors, including wine, beer, and liquor consumption, at the baseline. Prospective follow\u2010up for survival was conducted for 4966 CRC cases. Cox regression was used to compare nondrinkers with individuals who consumed, on average, 1 or more servings of alcohol per day in the years preceding their CRC diagnosis with respect to overall and disease\u2010specific survival. Separate analyses by beverage type, stratified by patient and tumor attributes, were also performed. All models were adjusted for the age at diagnosis, sex, study site, year of diagnosis, smoking history, body mass index, and education.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Prediagnostic beer and liquor consumption was not associated with CRC survival; however, higher levels of wine consumption were modestly associated with a better prognosis overall (CRC\u2010specific hazard ratio [HR], 0.70, 95% confidence interval [CI], 0.48\u20101.03; overall HR, 0.70; 95% CI, 0.53\u20100.94). Similar patterns were noted in stratified analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>These findings suggest that prediagnostic wine consumption is modestly associated with more favorable survival after CRC. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:1035\u201343.<\/jats:bold> \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30446","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T13:43:00Z","timestamp":1478612580000},"page":"1035-1043","source":"Crossref","is-referenced-by-count":22,"title":["Prediagnostic alcohol consumption and colorectal cancer survival: The Colon Cancer Family Registry"],"prefix":"10.1002","volume":"123","author":[{"given":"Amanda I.","family":"Phipps","sequence":"first","affiliation":[{"name":"Epidemiology Department University of Washington Seattle Washington"},{"name":"Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamaica R.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Epidemiology Department University of Washington Seattle Washington"},{"name":"Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter T.","family":"Campbell","sequence":"additional","affiliation":[{"name":"American Cancer Society Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aung Ko","family":"Win","sequence":"additional","affiliation":[{"name":"Melbourne School of Population and Global Health University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane C.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine University of Southern California Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noralane M.","family":"Lindor","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Scottsdale Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polly A.","family":"Newcomb","sequence":"additional","affiliation":[{"name":"Epidemiology Department University of Washington Seattle Washington"},{"name":"Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,8]]},"reference":[{"volume-title":"Colorectal Cancer Facts & Figures 2014\u20102016","year":"2014","author":"American Cancer Society","key":"e_1_2_8_2_1"},{"volume-title":"Alcohol Consumption and Ethyl Carbamate","year":"2010","author":"International Agency for Research on 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