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Although several studies have identified clinical and pathological features associated with <jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>V600<\/jats:italic><\/jats:sup> and <jats:italic>NRAS<\/jats:italic> mutations, limited data are available regarding the correlates and significance of <jats:italic>TP53<\/jats:italic> and <jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>Non\u2010V600<\/jats:italic><\/jats:sup> mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This study analyzed the patient demographics, primary tumor features, and clinical outcomes of a large cohort of non\u2010acral cutaneous melanoma patients who had undergone clinically indicated molecular testing (n\u2009=\u2009926).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The prevalence of <jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>V600<\/jats:italic><\/jats:sup>, <jats:italic>NRAS, TP53<\/jats:italic>, and <jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>Non\u2010V600<\/jats:italic><\/jats:sup> mutations was 43%, 21%, 19%, and 7%, respectively. The presence of a <jats:italic>TP53<\/jats:italic> mutation was associated with older age (<jats:italic>P<\/jats:italic>\u2009=\u2009.019), a head and neck primary tumor site (<jats:italic>P<\/jats:italic>\u2009=\u2009.0001), and longer overall survival (OS) from the diagnosis of stage IV disease in univariate (<jats:italic>P<\/jats:italic>\u2009=\u2009.039) and multivariate analyses (<jats:italic>P<\/jats:italic>\u2009=\u2009.015). <jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>Non\u2010V600<\/jats:italic><\/jats:sup> mutations were associated with older age (<jats:italic>P<\/jats:italic>\u2009=\u2009.005) but not with primary tumor features or OS from stage IV. Neither <jats:italic>TP53<\/jats:italic> nor <jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>Non\u2010V600<\/jats:italic><\/jats:sup> mutations correlated significantly with OS with frontline ipilimumab treatment, and the <jats:italic>TP53<\/jats:italic> status was not significantly associated with outcomes with frontline BRAF inhibitor therapy. Eleven patients with <jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>Non\u2010V600<\/jats:italic><\/jats:sup> mutations were treated with a BRAF inhibitor. Three patients were not evaluable for a response because of treatment cessation for toxicities; the remaining patients had disease progression as the best response to therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>These results add to the understanding of the clinical features associated with <jats:italic>TP53<\/jats:italic> and <jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>Non\u2010V600<\/jats:italic><\/jats:sup> mutations in advanced cutaneous melanoma patients, and they support the rationale for evaluating the prognostic significance of <jats:italic>TP53<\/jats:italic> in other cohorts of melanoma patients. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:1372\u20131381.<\/jats:bold> \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30463","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T12:21:23Z","timestamp":1480681283000},"page":"1372-1381","source":"Crossref","is-referenced-by-count":43,"title":["Clinicopathological features and clinical outcomes associated with <i>TP53<\/i> and <i>BRAF<\/i><sup><i>N<\/i><\/sup><sup><i>on\u2010<\/i><\/sup><sup><i>V<\/i><\/sup><sup><i>600<\/i><\/sup> mutations in cutaneous melanoma patients"],"prefix":"10.1002","volume":"123","author":[{"given":"Dae Won","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Moffitt Cancer Center Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Haydu","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aron Y.","family":"Joon","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Roland L.","family":"Bassett","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan E.","family":"Siroy","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Tetzlaff","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas"},{"name":"Department of Translational Molecular 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L.","family":"McQuade","sequence":"additional","affiliation":[{"name":"Department of Melanoma Medical Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kemnade","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Hwu","sequence":"additional","affiliation":[{"name":"Department of Melanoma Medical Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott E.","family":"Woodman","sequence":"additional","affiliation":[{"name":"Department of Melanoma Medical Oncology The University of Texas MD Anderson Cancer Center Houston Texas"},{"name":"Department of Systems Biology The University of Texas MD Anderson Cancer Center Houston 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