{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T04:46:29Z","timestamp":1782017189861,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T00:00:00Z","timestamp":1482278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Single\u2010modality radiotherapy is considered a standard\u2010of\u2010care option for certain stage III, T1\u20102N1 head and neck squamous cell carcinomas (HNSCCs). The role of concomitant chemoradiation is not well established because there have been no studies comparing chemoradiation with radiation alone in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This study analyzed patients in the National Cancer Data Base with cT1\u20102N1M0 invasive squamous cell carcinomas of the oropharynx, larynx, and hypopharynx who were diagnosed between 2004 and 2012 and were undergoing definitive radiation. Patients who were undergoing surgery before radiation with unknown follow\u2010up or for whom either the receipt or timing of chemotherapy was unknown were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In all, 5030 patients with T1\u20102N1 oropharyngeal, laryngeal, or hypopharyngeal cancer were included. The median follow\u2010up was 56.8 months (95% confidence interval [CI], 55.7\u201058.6 months). Overall, 68% of the patients received concomitant chemoradiation (CCRT). The use of CCRT significantly increased during the time period of this study from 53% in 2004 to 78% in 2012 (<jats:italic>P<\/jats:italic> &lt; .001). CCRT was associated with improved overall survival (OS) in comparison with radiation alone in a multivariate analysis (hazard ratio [HR], 0.80; 95% CI, 0.72\u20100.88; <jats:italic>P<\/jats:italic> &lt; .001). In propensity score\u2013adjusted analyses, CCRT remained significantly associated with improved OS, with 5\u2010year OS rates of 63.5% (95% CI, 60.7%\u201066.2%) and 55.6% (95% CI, 52.7%\u201058.4%; <jats:italic>P<\/jats:italic> &lt; .001) with CCRT and radiation alone, respectively. Subgroup analyses showed a benefit across the majority of subgroups, including patients with oropharyngeal cancer (HR, 0.74; 95% CI, 0.65\u20100.85; <jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Concomitant chemoradiation is associated with improved survival for patients with T1\u20102N1 HNSCC. Prospective trials in this population should be pursued. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:1555\u20131565.<\/jats:bold> \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30508","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T10:51:25Z","timestamp":1482317485000},"page":"1555-1565","source":"Crossref","is-referenced-by-count":15,"title":["Impact of concomitant chemoradiation on survival for patients with T1\u20102N1 head and neck cancer"],"prefix":"10.1002","volume":"123","author":[{"given":"Zachary S.","family":"Zumsteg","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Cedars\u2010Sinai Medical Center Los Angeles California"},{"name":"Samuel Oschin Comprehensive Cancer Institute Cedars\u2010Sinai Medical Center Los Angeles 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Cedars\u2010Sinai Medical Center Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mourad","family":"Tighiouart","sequence":"additional","affiliation":[{"name":"Samuel Oschin Comprehensive Cancer Institute Cedars\u2010Sinai Medical Center Los Angeles California"},{"name":"Department of Biostatistics and Bioinformatics Cedars\u2010Sinai Medical Center Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Shiao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cedars\u2010Sinai Medical Center Los Angeles California"},{"name":"Samuel Oschin Comprehensive Cancer Institute Cedars\u2010Sinai Medical Center Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Scher","sequence":"additional","affiliation":[{"name":"Samuel Oschin Comprehensive Cancer Institute Cedars\u2010Sinai Medical Center Los Angeles 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