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Increasing evidence supports the hypothesis that the fallopian tube is the site of origin for the vast majority of high\u2010grade serous carcinomas. Our growing understanding of the pathogenesis of this disease offers a rare opportunity to explore new preventive measures, such as bilateral salpingectomy, which may provide great benefit without compromising ovarian function. If the tubal paradigm is accurate, then the impact of bilateral salpingectomy could extend to <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> mutation carriers, high\u2010risk noncarriers, and average\u2010risk women. The authors present a review of the literature on the role of risk\u2010reducing salpingectomy in all women and in high\u2010risk groups, with a focus on morbidity, ovarian function, potential clinical applicability, and epidemiological considerations. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:1714\u20131720<\/jats:bold>. \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/cncr.30528","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T06:31:11Z","timestamp":1490337071000},"page":"1714-1720","source":"Crossref","is-referenced-by-count":36,"title":["Risk\u2010reducing salpingectomy: Let us be opportunistic"],"prefix":"10.1002","volume":"123","author":[{"given":"Kara C.","family":"Long Roche","sequence":"first","affiliation":[{"name":"Gynecology Service, Department of Surgery Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem R.","family":"Abu\u2010Rustum","sequence":"additional","affiliation":[{"name":"Gynecology Service, Department of Surgery Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melica","family":"Nourmoussavi","sequence":"additional","affiliation":[{"name":"Gynecology Service, Department of Surgery Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Zivanovic","sequence":"additional","affiliation":[{"name":"Gynecology Service, Department of Surgery Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041842"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.766"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.09.031"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1407"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.2078.13.12"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.5495"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020119"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012158"},{"key":"e_1_2_10_11_1","first-page":"pii","article-title":"Bilateral oophorectomy and breast cancer risk in BRCA1 and BRCA2 Mutation carriers [serial online]","volume":"109","author":"Kotsopoulos J","year":"2016","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-11-0430"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181a11c64"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70869-5"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181a106d4"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12033"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)92335-X"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940401)73:7<1859::AID-CNCR2820730714>3.0.CO;2-L"},{"key":"e_1_2_10_19_1","first-page":"717","article-title":"Determinants of ovarian cancer risk. 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