{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:17:50Z","timestamp":1792271870695,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,5,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The use of posttransplant cyclophosphamide (PT\u2010Cy) has contributed significantly to the success of haploidentical hematopoietic cell transplantation (HCT). Furthermore, several studies have shown promising results in the human leukocyte antigen\u2013matched setting. However, the use of high\u2010dose cyclophosphamide has been associated with the development of cardiomyopathy. There is a paucity of data concerning posttransplant cardiac complications in patients undergoing PT\u2010Cy\u2013based HCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A retrospective analysis of 176 patients undergoing HCT with PT\u2010Cy was performed. The overall survival, left ventricular ejection fractions, brain natriuretic peptide levels, and cardiac comorbidities were reviewed. The associations between comorbidities and the onset of heart failure were assessed with a Cox proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Pretransplant cardiomyopathy was found in 16 patients (9.1%) but had no effect on their posttransplant overall survival. Thirty\u2010five patients (21.9%) developed posttransplant cardiomyopathy, which correlated with increased mortality, but this was not statistically different from the frequency\u2010matched non\u2013PT\u2010Cy cohort. The majority of these cardiomyopathies occurred in the setting of an infectious milieu. An age greater than 60 years and an HCT comorbidity index score equal to or greater than 4 were the only risk factors that correlated with posttransplant cardiomyopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The presence of pretransplant cardiomyopathy does not negatively affect overall survival for patients who undergo HCT with PT\u2010Cy. Furthermore, cardiomyopathy in PT\u2010Cy patients is not caused by PT\u2010Cy but is mostly concurrent with infectious complications and is associated with reduced overall survival. Traditional cardiovascular risk factors do not fully predict the occurrence of posttransplant cardiomyopathy. Future research is required to unravel predictive factors for cardiomyopathy after PT\u2010Cy\u2013based HCT. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:1800\u20131809<\/jats:bold>. \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30534","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T08:02:44Z","timestamp":1488787364000},"page":"1800-1809","source":"Crossref","is-referenced-by-count":47,"title":["Cardiomyopathy in patients after posttransplant cyclophosphamide\u2013based hematopoietic cell transplantation"],"prefix":"10.1002","volume":"123","author":[{"given":"Chien\u2010Jung","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine, Washington University School of Medicine Saint Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin M.","family":"Vader","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine, Washington University School of Medicine Saint Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8092-6644","authenticated-orcid":false,"given":"Michael","family":"Slade","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant and Leukemia Program Department of Medicine, Washington University School of Medicine Saint Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"DiPersio","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant and Leukemia Program Department of Medicine, Washington University School of Medicine Saint Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Westervelt","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant and Leukemia Program 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